DC Field | Value | Language |
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dc.contributor.author | Kyung-Sook Chung | - |
dc.contributor.author | G Han | - |
dc.contributor.author | Bo Kyung Kim | - |
dc.contributor.author | H M Kim | - |
dc.contributor.author | J S Yang | - |
dc.contributor.author | Jiwon Ahn | - |
dc.contributor.author | K Lee | - |
dc.contributor.author | K B Song | - |
dc.contributor.author | Mi Sun Won | - |
dc.date.accessioned | 2017-04-19T09:47:33Z | - |
dc.date.available | 2017-04-19T09:47:33Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0344-5704 | - |
dc.identifier.uri | 10.1007/s00280-013-2310-y | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11699 | - |
dc.description.abstract | Purpose: We investigated the action mechanism of a novel anticancer compound, KR28 (1-allyl-4-dodecanoyl-1-ethyl-piperazin-1-ium; bromide), to induce apoptosis of human prostate carcinoma PC-3 cells. Methods: To explore an apoptotic signaling of KR28, we used ROS assay, SRB assay, flow cytometry analysis, reporter assay, xenograft assay, Western blotting, and RT-PCR analysis. Results: The growth inhibitory action of KR28 is cell line specific, impeding the growth of prostate carcinoma PC-3 and stomach carcinoma NUGC-3 cells. KR28 showed strong antitumor activity in PC-3 mouse xenograft model. KR28 increased ROS production, leading to nuclear c-Abl expression, which in turn activated p38 mitogen-activated protein kinase (MAPK) to enhance the expression of RhoB, an apoptosis inducer. The KR28-induced apoptosis was abrogated by the ROS scavenger N-acetylcysteine and by knockdown of c-Abl, p38 MAPK, or ATF2. Moreover, the p300 binding site and two CCAAT boxes in the RhoB promoter appear to be involved in ROS-mediated RhoB expression in the presence of KR28. Conclusion: The antitumor agent KR28 induces apoptosis of PC-3 cells by ROS-mediated RhoB expression via c-Abl upregulation and activation of p38 MAPK/ATF-2. | - |
dc.publisher | Springer | - |
dc.title | A novel antitumor piperazine alkyl compound causes apoptosis by inducing RhoB expression via ROS-mediated c-Abl/p38 MAPK signaling | - |
dc.title.alternative | A novel antitumor piperazine alkyl compound causes apoptosis by inducing RhoB expression via ROS-mediated c-Abl/p38 MAPK signaling | - |
dc.type | Article | - |
dc.citation.title | Cancer Chemotherapy and Pharmacology | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 1324 | - |
dc.citation.startPage | 1315 | - |
dc.citation.volume | 72 | - |
dc.contributor.affiliatedAuthor | Kyung-Sook Chung | - |
dc.contributor.affiliatedAuthor | Bo Kyung Kim | - |
dc.contributor.affiliatedAuthor | Jiwon Ahn | - |
dc.contributor.affiliatedAuthor | Mi Sun Won | - |
dc.contributor.alternativeName | 정경숙 | - |
dc.contributor.alternativeName | 한균희 | - |
dc.contributor.alternativeName | 김보경 | - |
dc.contributor.alternativeName | 김환묵 | - |
dc.contributor.alternativeName | 양지선 | - |
dc.contributor.alternativeName | 안지원 | - |
dc.contributor.alternativeName | 이경 | - |
dc.contributor.alternativeName | 송경빈 | - |
dc.contributor.alternativeName | 원미선 | - |
dc.identifier.bibliographicCitation | Cancer Chemotherapy and Pharmacology, vol. 72, pp. 1315-1324 | - |
dc.identifier.doi | 10.1007/s00280-013-2310-y | - |
dc.subject.keyword | c-Abl | - |
dc.subject.keyword | p38 MAPK | - |
dc.subject.keyword | Prostate cancer | - |
dc.subject.keyword | RhoB | - |
dc.subject.keyword | ROS | - |
dc.subject.local | c-Abl | - |
dc.subject.local | p38 MAP kinase | - |
dc.subject.local | p38 mitogen-activated protein kinase (p38 MARK) | - |
dc.subject.local | P38 MAPK | - |
dc.subject.local | p38 mitogen-activated protein kinase | - |
dc.subject.local | p38 MAPK | - |
dc.subject.local | p38MAPK | - |
dc.subject.local | prostate cancer | - |
dc.subject.local | Prostate cancer | - |
dc.subject.local | RhoB | - |
dc.subject.local | Rhob | - |
dc.subject.local | Reactive oxidative species | - |
dc.subject.local | Reactive oxygen species(ROS) | - |
dc.subject.local | Reactive oxygen species | - |
dc.subject.local | Reactive Oxygen Species (ROS) | - |
dc.subject.local | Reactive Oxygen Species | - |
dc.subject.local | ROS | - |
dc.subject.local | Reactive oxygen species (ROS) | - |
dc.subject.local | reactive oxygen species | - |
dc.subject.local | reactive oxygen species (ROS) | - |
dc.description.journalClass | Y | - |
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