Activity-guided screening of anti-inflammatory compounds from the hexane extracts of Schisandra chinensis fruit = 생리활성분획 추적방법을 통한 오미자 추출물의 항염증 활성 분석

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dc.contributor.authorH J Choi-
dc.contributor.authorY W Choi-
dc.contributor.authorS Y Baek-
dc.contributor.authorB S Kim-
dc.contributor.authorS C Ahn-
dc.contributor.authorMoon Soo Rhee-
dc.contributor.authorS Yoon-
dc.date.accessioned2017-04-19T09:47:50Z-
dc.date.available2017-04-19T09:47:50Z-
dc.date.issued2013-
dc.identifier.issnI000-0128-
dc.identifier.uri10.5352/JLS.2013.23.2.311ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11713-
dc.description.abstractSchisandra chinensis containing a variety of pharmacologically active lignans has been traditionally used in oriental medicine. In this study, anti-inflammatory compounds were screened from the hexane extracts of S. chinensis by activity-guided fractionation. First, we investigated the regulatory effects on the expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) with 38 fractions from the hexane extracts of S. chinensis in human umbilical vein endothelial cells (HUVECs). As a result, SCKH1 among the 38 fractions from the hexane extract of S. chinensis was selected for further analysis based on its unique regulatory effect on cell adhesion molecules, especially on VCAM-1, in LPS-stimulated HUVECs. The subsequent activity-guided fractionation of SCKH1 resulted in the purification of SCKH1PAIBPB, which was found to suppress the expression of VCAM-1, MCP-1, IL-6 and IL-8 in HUVECs stimulated with LPS, and to inhibit the adhesive capacity between HUVECs and monocytes. Taken together, our data indicate that SCKH1PAIBPB can be proposed as an effective anti-inflammatory compound that may have a potential therapeutic use for the prevention and treatment of various inflammatory diseases as well as ischemic vascular diseases.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleActivity-guided screening of anti-inflammatory compounds from the hexane extracts of Schisandra chinensis fruit = 생리활성분획 추적방법을 통한 오미자 추출물의 항염증 활성 분석-
dc.title.alternativeActivity-guided screening of anti-inflammatory compounds from the hexane extracts of Schisandra chinensis fruit-
dc.typeArticle-
dc.citation.titleJournal of Life Science-
dc.citation.number2-
dc.citation.endPage318-
dc.citation.startPage311-
dc.citation.volume23-
dc.contributor.affiliatedAuthorMoon Soo Rhee-
dc.contributor.alternativeName최희정-
dc.contributor.alternativeName최영환-
dc.contributor.alternativeName백선용-
dc.contributor.alternativeName김봉선-
dc.contributor.alternativeName안순철-
dc.contributor.alternativeName이문수-
dc.contributor.alternativeName윤식-
dc.identifier.bibliographicCitationJournal of Life Science, vol. 23, no. 2, pp. 311-318-
dc.identifier.doi10.5352/JLS.2013.23.2.311-
dc.subject.keywordActivity-guided isolation-
dc.subject.keywordanti-inflammatory-
dc.subject.keywordcell adhesion molecule-
dc.subject.keywordSchisandra chinensis-
dc.subject.keywordSCKH1PAIBPB-
dc.subject.localActivity-guided isolation-
dc.subject.localanti-inflammatory-
dc.subject.localAnti-inflammatory-
dc.subject.localCell adhesion molecule-
dc.subject.localcell adhesion molecule-
dc.subject.localCell adhesion molecules-
dc.subject.localSchisandra chinensis-
dc.subject.localSCKH1PAIBPB-
dc.description.journalClassN-
Appears in Collections:
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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