DC Field | Value | Language |
---|---|---|
dc.contributor.author | H J Choi | - |
dc.contributor.author | Y W Choi | - |
dc.contributor.author | S Y Baek | - |
dc.contributor.author | B S Kim | - |
dc.contributor.author | S C Ahn | - |
dc.contributor.author | Moon Soo Rhee | - |
dc.contributor.author | S Yoon | - |
dc.date.accessioned | 2017-04-19T09:47:50Z | - |
dc.date.available | 2017-04-19T09:47:50Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | I000-0128 | - |
dc.identifier.uri | 10.5352/JLS.2013.23.2.311 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11713 | - |
dc.description.abstract | Schisandra chinensis containing a variety of pharmacologically active lignans has been traditionally used in oriental medicine. In this study, anti-inflammatory compounds were screened from the hexane extracts of S. chinensis by activity-guided fractionation. First, we investigated the regulatory effects on the expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) with 38 fractions from the hexane extracts of S. chinensis in human umbilical vein endothelial cells (HUVECs). As a result, SCKH1 among the 38 fractions from the hexane extract of S. chinensis was selected for further analysis based on its unique regulatory effect on cell adhesion molecules, especially on VCAM-1, in LPS-stimulated HUVECs. The subsequent activity-guided fractionation of SCKH1 resulted in the purification of SCKH1PAIBPB, which was found to suppress the expression of VCAM-1, MCP-1, IL-6 and IL-8 in HUVECs stimulated with LPS, and to inhibit the adhesive capacity between HUVECs and monocytes. Taken together, our data indicate that SCKH1PAIBPB can be proposed as an effective anti-inflammatory compound that may have a potential therapeutic use for the prevention and treatment of various inflammatory diseases as well as ischemic vascular diseases. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Activity-guided screening of anti-inflammatory compounds from the hexane extracts of Schisandra chinensis fruit = 생리활성분획 추적방법을 통한 오미자 추출물의 항염증 활성 분석 | - |
dc.title.alternative | Activity-guided screening of anti-inflammatory compounds from the hexane extracts of Schisandra chinensis fruit | - |
dc.type | Article | - |
dc.citation.title | Journal of Life Science | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 318 | - |
dc.citation.startPage | 311 | - |
dc.citation.volume | 23 | - |
dc.contributor.affiliatedAuthor | Moon Soo Rhee | - |
dc.contributor.alternativeName | 최희정 | - |
dc.contributor.alternativeName | 최영환 | - |
dc.contributor.alternativeName | 백선용 | - |
dc.contributor.alternativeName | 김봉선 | - |
dc.contributor.alternativeName | 안순철 | - |
dc.contributor.alternativeName | 이문수 | - |
dc.contributor.alternativeName | 윤식 | - |
dc.identifier.bibliographicCitation | Journal of Life Science, vol. 23, no. 2, pp. 311-318 | - |
dc.identifier.doi | 10.5352/JLS.2013.23.2.311 | - |
dc.subject.keyword | Activity-guided isolation | - |
dc.subject.keyword | anti-inflammatory | - |
dc.subject.keyword | cell adhesion molecule | - |
dc.subject.keyword | Schisandra chinensis | - |
dc.subject.keyword | SCKH1PAIBPB | - |
dc.subject.local | Activity-guided isolation | - |
dc.subject.local | anti-inflammatory | - |
dc.subject.local | Anti-inflammatory | - |
dc.subject.local | Cell adhesion molecule | - |
dc.subject.local | cell adhesion molecule | - |
dc.subject.local | Cell adhesion molecules | - |
dc.subject.local | Schisandra chinensis | - |
dc.subject.local | SCKH1PAIBPB | - |
dc.description.journalClass | N | - |
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