DC Field | Value | Language |
---|---|---|
dc.contributor.author | Y S Jang | - |
dc.contributor.author | W Kang | - |
dc.contributor.author | D Y Chang | - |
dc.contributor.author | P S Sung | - |
dc.contributor.author | Bum Chan Park | - |
dc.contributor.author | S H Yoo | - |
dc.contributor.author | Young Woo Park | - |
dc.contributor.author | E C Shin | - |
dc.date.accessioned | 2017-04-19T09:48:01Z | - |
dc.date.available | 2017-04-19T09:48:01Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1521-6616 | - |
dc.identifier.uri | 10.1016/j.clim.2013.09.007 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11727 | - |
dc.description.abstract | We investigated regulation of human NK cell function by CD27 engagement using a recombinant soluble CD70 protein. CD27 was preferentially expressed on CD56bright NK cells, and soluble CD70 protein bound to CD27+CD56bright NK cells. While soluble CD70 protein enhanced IFN-γ secretion by CD56bright NK cells in the presence of IL-12, it augmented neither cytolytic activity nor proliferation of NK cells. Thus, we next asked if soluble CD70 protein could be used to induce non-cytolytic antiviral activity of NK cells using an in vitro hepatitis C virus (HCV) infection system. Soluble CD70 protein stimulated NK cells to suppress HCV replication by enhancing NK cell IFN-γ secretion without killing infected cells. Taken together, we demonstrate that CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright NK cells by IFN-γ secretion. Thus, this soluble CD70 protein may be useful for the treatment of viral infections such as HCV infection. | - |
dc.publisher | Elsevier | - |
dc.title | CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright natural killer cells by IFN-γ secretion | - |
dc.title.alternative | CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright natural killer cells by IFN-γ secretion | - |
dc.type | Article | - |
dc.citation.title | Clinical Immunology | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 387 | - |
dc.citation.startPage | 379 | - |
dc.citation.volume | 149 | - |
dc.contributor.affiliatedAuthor | Bum Chan Park | - |
dc.contributor.affiliatedAuthor | Young Woo Park | - |
dc.contributor.alternativeName | 장영순 | - |
dc.contributor.alternativeName | 강원석 | - |
dc.contributor.alternativeName | 장동엽 | - |
dc.contributor.alternativeName | 성필수 | - |
dc.contributor.alternativeName | 박범찬 | - |
dc.contributor.alternativeName | 유석호 | - |
dc.contributor.alternativeName | 박영우 | - |
dc.contributor.alternativeName | 신의철 | - |
dc.identifier.bibliographicCitation | Clinical Immunology, vol. 149, no. 3, pp. 379-387 | - |
dc.identifier.doi | 10.1016/j.clim.2013.09.007 | - |
dc.subject.keyword | CD27 | - |
dc.subject.keyword | CD70 | - |
dc.subject.keyword | Hepatitis C virus | - |
dc.subject.keyword | IFN-γ | - |
dc.subject.keyword | Natural killer cells | - |
dc.subject.local | CD27 | - |
dc.subject.local | CD70 | - |
dc.subject.local | hepatitis C virus | - |
dc.subject.local | Hepatitis C virus | - |
dc.subject.local | IFN-γ | - |
dc.subject.local | Ifn-γ | - |
dc.subject.local | IFN-gamma | - |
dc.subject.local | Natural killer cell | - |
dc.subject.local | Natural killer cells | - |
dc.subject.local | natural killer (NK) cells | - |
dc.subject.local | natural killer cell | - |
dc.description.journalClass | Y | - |
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