The effect of metformin treatment on CRBP-I Level and cancer development in the liver of HBx transgenic mice

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dc.contributor.authorJ H Kim-
dc.contributor.authorM M Alam-
dc.contributor.authorD B Park-
dc.contributor.authorM Cho-
dc.contributor.authorS H Lee-
dc.contributor.authorY J Jeon-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorT D Kim-
dc.contributor.authorH Y Kim-
dc.contributor.authorC G Cho-
dc.contributor.authorD H Lee-
dc.date.accessioned2017-04-19T09:48:04Z-
dc.date.available2017-04-19T09:48:04Z-
dc.date.issued2013-
dc.identifier.issn1226-4512-
dc.identifier.uri10.4196/kjpp.2013.17.5.455ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11738-
dc.description.abstractRetinoids regulate not only various cell functions including proliferation and differentiation but also glucose and lipid metabolism. After we observed a marked up-regulation of cellular retinol-binding protein-I (CRBP-I) in the liver of hepatitis B virus x antigen (HBx)-transgenic (HBx Tg) mice which are prone to hepatocellular carcinoma (HCC) and fatty liver, we aimed to evaluate retinoid pathway, including genes for the retinoid physiology, CRBP-I protein expression, and retinoid levels, in the liver of HBx Tg mice. We also assessed the effect of chronic metformin treatment on HCC development in the mice. Many genes involved in hepatic retinoid physiology, including CRBP-I, were altered and the tissue levels of retinol and all-trans retinoic acid (ATRA) were elevated in the liver of HBx Tg mice compared to those of wild type (WT) control mice. CRBP-I protein expression in liver, but not in white adipose tissue, of HBx Tg mice was significantly elevated compared to WT control mice while CRBP-I protein expressions in the liver and WAT of high-fat fed obese and db/db mice were comparable to WT control mice. Chronic treatment of HBx Tg mice with metformin did not affect the incidence of HCC, but slightly increased hepatic CRBP-I level. In conclusion, hepatic CRBP-I level was markedly up-regulated in HCC-prone HBx Tg mice and neither hepatic CRBP-I nor the development of HCC was suppressed by metformin treatment.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleThe effect of metformin treatment on CRBP-I Level and cancer development in the liver of HBx transgenic mice-
dc.title.alternativeThe effect of metformin treatment on CRBP-I Level and cancer development in the liver of HBx transgenic mice-
dc.typeArticle-
dc.citation.titleKorean Journal of Physiology & Pharmacology-
dc.citation.number5-
dc.citation.endPage461-
dc.citation.startPage455-
dc.citation.volume17-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.alternativeName김조헌-
dc.contributor.alternativeNameAlam-
dc.contributor.alternativeName박덕배-
dc.contributor.alternativeName조문재-
dc.contributor.alternativeName이승홍-
dc.contributor.alternativeName전유진-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName김태두-
dc.contributor.alternativeName김하영-
dc.contributor.alternativeName조청구-
dc.contributor.alternativeName이대호-
dc.identifier.bibliographicCitationKorean Journal of Physiology & Pharmacology, vol. 17, no. 5, pp. 455-461-
dc.identifier.doi10.4196/kjpp.2013.17.5.455-
dc.subject.keywordCellular retinol-binding protein-I-
dc.subject.keywordHBx protein-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordMetformin-
dc.subject.keywordRetinoids-
dc.subject.localCellular retinol-binding protein-I-
dc.subject.localHBx protein-
dc.subject.localHepatocellular carcinomas-
dc.subject.localHepatocellular carcinoma (HCC)-
dc.subject.localHepatocellular carcinoma-
dc.subject.localhepatocellular carcinoma (HCC)-
dc.subject.localhepatocellular carcinoma-
dc.subject.localmetformin-
dc.subject.localMetformin-
dc.subject.localRetinoids-
dc.subject.localretinoids-
dc.description.journalClassY-
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