DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh Hyung Kwon | - |
dc.contributor.author | Jong Hwan Kim | - |
dc.contributor.author | Seon-Young Kim | - |
dc.contributor.author | Yong Sung Kim | - |
dc.date.accessioned | 2017-04-19T09:48:04Z | - |
dc.date.available | 2017-04-19T09:48:04Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | 10.3892/ijo.2013.2211 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11739 | - |
dc.description.abstract | Chemoresistance is one of the most serious problems in the treatment of cancer. In the present study, we show that Fn14 promotes resistance to 5-fluorouracil (5-FU) in gastric cancer (GC). We found that 5-FU treatment upregulated Fn14 expression in various cancer cell lines, including GC cell lines, and that knockdown of Fn14 using shRNA accelerated 5-FU sensitivity. In contrast, Fn14 overexpression or TWEAK treatment promoted resistance to 5-FU. Furthermore, we investigated the mechanisms underlying Fn14-mediated chemoresistance. We first revealed that 5-FU-mediated upregulation of Fn14 occurred as a result of NF-κB activation, indicating that 5-FU-mediated NF-κB activation was the principal event underlying Fn14 upregulation and 5-FU resistance in GC. Taken together, our results suggest that Fn14 is a novel therapeutic target and that inhibition of Fn14 combined with 5-FU treatment may be an effective molecular therapeutic strategy to treat 5-FU-resistant gastric cancers | - |
dc.publisher | Spandidos Publ Ltd | - |
dc.title | TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-kB activation | - |
dc.title.alternative | TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-kB activation | - |
dc.type | Article | - |
dc.citation.title | International Journal of Oncology | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 590 | - |
dc.citation.startPage | 583 | - |
dc.citation.volume | 44 | - |
dc.contributor.affiliatedAuthor | Oh Hyung Kwon | - |
dc.contributor.affiliatedAuthor | Jong Hwan Kim | - |
dc.contributor.affiliatedAuthor | Seon-Young Kim | - |
dc.contributor.affiliatedAuthor | Yong Sung Kim | - |
dc.contributor.alternativeName | 권오형 | - |
dc.contributor.alternativeName | 김종환 | - |
dc.contributor.alternativeName | 김선영 | - |
dc.contributor.alternativeName | 김용성 | - |
dc.identifier.bibliographicCitation | International Journal of Oncology, vol. 44, no. 2, pp. 583-590 | - |
dc.identifier.doi | 10.3892/ijo.2013.2211 | - |
dc.subject.keyword | chemoresistance | - |
dc.subject.keyword | 5-FU | - |
dc.subject.keyword | gastric cancer | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | Fn14 | - |
dc.subject.local | chemoresistance | - |
dc.subject.local | Chemoresistance | - |
dc.subject.local | Chemo-resistance | - |
dc.subject.local | 5-FU | - |
dc.subject.local | gastric cancer | - |
dc.subject.local | Gastric cancer (GC) | - |
dc.subject.local | Gastric cancer | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.subject.local | Fn14 | - |
dc.description.journalClass | Y | - |
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