Verrulactone C with an unprecedented dispiro skeleton, a new inhibitor of Staphylococcus aureus enoyl-ACP reductase, from Penicillium verruculosum F375

Cited 28 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorNyung Kim-
dc.contributor.authorM J Sohn-
dc.contributor.authorH Koshino-
dc.contributor.authorE H Kim-
dc.contributor.authorWon Gon Kim-
dc.date.accessioned2017-04-19T09:49:19Z-
dc.date.available2017-04-19T09:49:19Z-
dc.date.issued2014-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2013.11.071ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11746-
dc.description.abstractAn highly quaternary and unprecedented dispiro compound, verrulactone C, with the known compound, altenuisol, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structures were established by various spectral analysis. Verrulactone C and altenuisol showed FabI-selective inhibition. Especially altenuisol had the high correlation between FabI-inhibition and whole cell antibacterial activity against Staphylococcus aureus and MRSA with MICs of 8-32 μg/mL.-
dc.publisherElsevier-
dc.titleVerrulactone C with an unprecedented dispiro skeleton, a new inhibitor of Staphylococcus aureus enoyl-ACP reductase, from Penicillium verruculosum F375-
dc.title.alternativeVerrulactone C with an unprecedented dispiro skeleton, a new inhibitor of Staphylococcus aureus enoyl-ACP reductase, from Penicillium verruculosum F375-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number1-
dc.citation.endPage86-
dc.citation.startPage83-
dc.citation.volume24-
dc.contributor.affiliatedAuthorWon Gon Kim-
dc.contributor.alternativeName김녕-
dc.contributor.alternativeName손미진-
dc.contributor.alternativeNameKoshino-
dc.contributor.alternativeName김은희-
dc.contributor.alternativeName김원곤-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 24, no. 1, pp. 83-86-
dc.identifier.doi10.1016/j.bmcl.2013.11.071-
dc.subject.keywordAntibacterial-
dc.subject.keywordDispiro-
dc.subject.keywordFabI-
dc.subject.keywordS. aureus-
dc.subject.localAntibacterials-
dc.subject.localantibacterials-
dc.subject.localantibacterial-
dc.subject.localAntibacterial-
dc.subject.localDispiro-
dc.subject.localFabI-
dc.subject.localS. aureus-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.