Discovery of coumarin derivatives as fluorescence acceptors for intrinsic fluorescence resonance energy transfer of proteins

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Title
Discovery of coumarin derivatives as fluorescence acceptors for intrinsic fluorescence resonance energy transfer of proteins
Author(s)
Ju Hwan Kim; J Sumranjit; H J Kang; Sang Jeon Chung
Bibliographic Citation
Molecular Biosystems, vol. 10, no. 1, pp. 30-33
Publication Year
2014
Abstract
Coumarin analogues were synthezised and evaluated as acceptors for the intrinsic fluorescence resonance energy transfer (iFRET) of tryptophan residues in target proteins. The fluorescence properties such as quantum yields, iFRET efficiencies, and Forster distances of the prepared coumarin analogs were determined in a model system, by their conjugation to biotin, utilizing streptavidin (SAV) as the iFRET donor. The coumarin derivatives reported here represent the most efficient iFRET acceptors for tryptophan, known to date.
ISSN
1742-206X
Publisher
Royal Soc Chemistry
DOI
http://dx.doi.org/10.1039/c3mb70323a
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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