Role of gangliosides in the differentiation of human mesenchymal-derived stem cells into osteoblasts and neuronal cells

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dc.contributor.authorG Moussavou-
dc.contributor.authorD H Kwak-
dc.contributor.authorM U Lim-
dc.contributor.authorJi-Su Kim-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorY K Choo-
dc.date.accessioned2017-04-19T09:49:34Z-
dc.date.available2017-04-19T09:49:34Z-
dc.date.issued2013-
dc.identifier.issn1225-8687-
dc.identifier.uri10.5483/BMBRep.2013.46.11.179ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11760-
dc.description.abstractGangliosides are complex glycosphingolipids that are the major component of cytoplasmic cell membranes, and play a role in the control of biological processes. Human mesenchymal stem cells (hMSCs) have received considerable attention as alternative sources of adult stem cells because of their potential to differentiate into multiple cell lineages. In this study, we focus on various functional roles of gangliosides in the differentiation of hMSCs into osteoblasts or neuronal cells. A relationship between gangliosides and epidermal growth factor receptor (EGFR) activation during osteoblastic differentiation of hMSCs was observed, and the gangliosides may play a major role in the regulation of the differentiation. The roles of gangliosides in osteoblast differentiation are dependent on the origin of hMSCs. The reduction of ganglioside biosynthesis inhibited the neuronal differentiation of hMSCs during an early stage of the differentiation process, and the ganglioside expression can be used as a marker for the identification of neuronal differentiation from hMSCs.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleRole of gangliosides in the differentiation of human mesenchymal-derived stem cells into osteoblasts and neuronal cells-
dc.title.alternativeRole of gangliosides in the differentiation of human mesenchymal-derived stem cells into osteoblasts and neuronal cells-
dc.typeArticle-
dc.citation.titleBMB Reports-
dc.citation.number11-
dc.citation.endPage532-
dc.citation.startPage527-
dc.citation.volume46-
dc.contributor.affiliatedAuthorJi-Su Kim-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.alternativeNameMoussavou-
dc.contributor.alternativeName곽동훈-
dc.contributor.alternativeName임맑음-
dc.contributor.alternativeName김지수-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName추영국-
dc.identifier.bibliographicCitationBMB Reports, vol. 46, no. 11, pp. 527-532-
dc.identifier.doi10.5483/BMBRep.2013.46.11.179-
dc.subject.keywordDifferentiation-
dc.subject.keywordGangliosides-
dc.subject.keywordHuman mesenchymal stem cells (hMSCs)-
dc.subject.keywordNeuronal cells-
dc.subject.keywordOsteoblasts-
dc.subject.localdifferentiation-
dc.subject.localDifferentiation-
dc.subject.localGanglioside-
dc.subject.localGangliosides-
dc.subject.localganglioside-
dc.subject.localHuman mesenchymal stem cells (hMSCs)-
dc.subject.localhuman mesenchymal stem cells-
dc.subject.localHuman mesenchymal stem cells-
dc.subject.localHuman mesenchymal stem cells (MSCs)-
dc.subject.localNeuronal cells-
dc.subject.localNeuronal cell-
dc.subject.localneuronal cell-
dc.subject.localOsteoblast-
dc.subject.localosteoblast-
dc.subject.localosteoblasts-
dc.subject.localOsteoblasts-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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