Anti-inflammatory activities of methanol extract of Mastixia arboria C.B. Clarke as to mouse macrophage and paw edema = 마스티시아 알보리아의 항염 효과

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Title
Anti-inflammatory activities of methanol extract of Mastixia arboria C.B. Clarke as to mouse macrophage and paw edema = 마스티시아 알보리아의 항염 효과
Author(s)
Hui Seong Kim; Ok-Kyoung Kwon; Ji Won Park; H G Jeong; Sei-Ryang Oh; Hyeong Kyu Lee; T T Bach; D V Hai; Kyung Seop Ahn
Bibliographic Citation
Bioscience Biotechnology and Biochemistry, vol. 77, no. 12, pp. 2356-2361
Publication Year
2013
Abstract
The biological activity of Mastixia arborea (MA) relates to inflammation, but the underlying mechanisms are largely unknown. We confirmed the anti-inflammatory effects of a methanol extract of MA extract on lipopolysaccharide (LPS)-stimulated RAW264.7 mouse macrophage cells and carrageenan-induced mice paw edema. The MA extract significantly inhibited nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), and IL-6 production in LPS-stimulated RAW264.7 cells. In vitro expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was suppressed by the extract. The extract attenuated acute inflammatory responses in carrageenan-induced mice paw edema. A mechanism study indicated that translocation of the NF-κB (p65) subunit into the nucleus and phosphorylation of ERK and JNK were inhibited by the extract. These results indicate that the extract is an effective suppressor of the inflammatory response, blocking the phosphorylation of ERK and JNK and the translocation of NF-κB in macrophages, thereby producing an anti-inflammatory effect in vivo.
Keyword
InflammationMAPKMastixia arboreaNF-κBNitric oxide
ISSN
0916-8451
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1271/bbb.130429
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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