ORF5-based evolutionary and epidemiological dynamics of the type 1 porcine reproductive and respiratory syndrome virus circulating in Korea

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dc.contributor.authorV G Nguyen-
dc.contributor.authorHye Kwon Kim-
dc.contributor.authorH J Moon-
dc.contributor.authorSeong-Jun Park-
dc.contributor.authorH C Chung-
dc.contributor.authorM K Choi-
dc.contributor.authorA R Kim-
dc.contributor.authorB K Park-
dc.date.accessioned2017-04-19T09:49:42Z-
dc.date.available2017-04-19T09:49:42Z-
dc.date.issued2014-
dc.identifier.issn1567-1348-
dc.identifier.uri10.1016/j.meegid.2013.11.023ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11775-
dc.description.abstractThis study applied a number of advanced genetic analysis tools to investigate the evolutionary trajectories and epidemiological dynamics of Korean type 1 PRRSV based on variations in the ORF5 gene over a long-term period from 2005 to 2013. Maximum likelihood phylogenetic analysis performed on large, worldwide ORF5 sequences (n= 1127) strongly suggested no further introduction of genetically novel type 1 PRRSV into Korean pig farms, with the identification of only two clusters (I and II) in circulation to date. Using a codon-based extension of the Bayesian relaxed clock model, this study was able to distinguish between synonymous and non-synonymous substitutions and demonstrated that, while the absolute rates of synonymous substitution (E[S]) were similar between clusters I and II, the absolute rate of non-synonymous substitution (E[N]) was significantly different between the clusters. Cluster I was found to have an elevated E[N]/. E[S] ratio relative to cluster II on the internal branches, compared to the external branches. Additionally, many fewer sites were predicted under diversifying selection in cluster II than in cluster I. Utilizing the Bayesian skyride method and the novel Bayesian birth-death skyline plot method, this study provided insights into the epidemiological dynamics of type 1 PRRSV in Korea by revealing that each cluster experienced a unique epidemic growth and by uncovering correlations between the effective population size and effective reproductive number.-
dc.publisherElsevier-
dc.titleORF5-based evolutionary and epidemiological dynamics of the type 1 porcine reproductive and respiratory syndrome virus circulating in Korea-
dc.title.alternativeORF5-based evolutionary and epidemiological dynamics of the type 1 porcine reproductive and respiratory syndrome virus circulating in Korea-
dc.typeArticle-
dc.citation.titleInfection Genetics and Evolution-
dc.citation.number0-
dc.citation.endPage328-
dc.citation.startPage320-
dc.citation.volume21-
dc.contributor.affiliatedAuthorHye Kwon Kim-
dc.contributor.affiliatedAuthorSeong-Jun Park-
dc.contributor.alternativeNameNguyen-
dc.contributor.alternativeName김혜권-
dc.contributor.alternativeName문형준-
dc.contributor.alternativeName박성준-
dc.contributor.alternativeName정희천-
dc.contributor.alternativeName최민경-
dc.contributor.alternativeName김아름-
dc.contributor.alternativeName박봉균-
dc.identifier.bibliographicCitationInfection Genetics and Evolution, vol. 21, pp. 320-328-
dc.identifier.doi10.1016/j.meegid.2013.11.023-
dc.subject.keywordEpidemiological dynamics-
dc.subject.keywordEvolutionary dynamics-
dc.subject.keywordKorean type 1 PRRSV-
dc.subject.localEpidemiological dynamics-
dc.subject.localEvolutionary dynamics-
dc.subject.localKorean type 1 PRRSV-
dc.description.journalClassY-
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