DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kyu-Sun Lee | - |
dc.contributor.author | Z Wu | - |
dc.contributor.author | Y Song | - |
dc.contributor.author | S S Mitra | - |
dc.contributor.author | A H Feroze | - |
dc.contributor.author | S H Cheshier | - |
dc.contributor.author | B Lu | - |
dc.date.accessioned | 2017-04-19T09:49:42Z | - |
dc.date.available | 2017-04-19T09:49:42Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | 10.1101/gad.225169.113 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11776 | - |
dc.description.abstract | The self-renewal versus differentiation choice of Drosophila and mammalian neural stem cells (NSCs) requires Notch (N) signaling. How N regulates NSC behavior is not well understood. Here we show that canonical N signaling cooperates with a noncanonical N signaling pathway to mediate N-directed NSC regulation. In the noncanonical pathway, N interacts with PTEN-induced kinase 1 (PINK1) to influence mitochondrial function, activating mechanistic target of rapamycin complex 2 (mTORC2)/AKT signaling. Importantly, attenuating noncanonical N signaling preferentially impaired the maintenance of Drosophila and human cancer stem cell-like tumor-forming cells. Our results emphasize the importance of mitochondria to N and NSC biology, with important implications for diseases associated with aberrant N signaling. | - |
dc.publisher | Cold Spring Harbor Lab Press, Publications Dept | - |
dc.title | Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway | - |
dc.title.alternative | Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway | - |
dc.type | Article | - |
dc.citation.title | Genes & Development | - |
dc.citation.number | 24 | - |
dc.citation.endPage | 2647 | - |
dc.citation.startPage | 2642 | - |
dc.citation.volume | 27 | - |
dc.contributor.affiliatedAuthor | Kyu-Sun Lee | - |
dc.contributor.alternativeName | 이규선 | - |
dc.contributor.alternativeName | Wu | - |
dc.contributor.alternativeName | Song | - |
dc.contributor.alternativeName | Mitra | - |
dc.contributor.alternativeName | Feroze | - |
dc.contributor.alternativeName | Cheshier | - |
dc.contributor.alternativeName | Lu | - |
dc.identifier.bibliographicCitation | Genes & Development, vol. 27, no. 24, pp. 2642-2647 | - |
dc.identifier.doi | 10.1101/gad.225169.113 | - |
dc.subject.keyword | Cancer stem cells | - |
dc.subject.keyword | Mitochondria | - |
dc.subject.keyword | mTORC2/AKT signaling | - |
dc.subject.keyword | Neural stem cells | - |
dc.subject.keyword | Notch | - |
dc.subject.keyword | PINK1 | - |
dc.subject.local | cancer stem cell | - |
dc.subject.local | Cancer stem cell (CSC) | - |
dc.subject.local | Cancer stem cell | - |
dc.subject.local | Cancer stem cells | - |
dc.subject.local | Cancer Stem Cells | - |
dc.subject.local | Mitochondria | - |
dc.subject.local | mitochondria | - |
dc.subject.local | mTORC2/AKT signaling | - |
dc.subject.local | neural stem cell | - |
dc.subject.local | Neural stem cell | - |
dc.subject.local | Neural stem cells | - |
dc.subject.local | Neural stem cells (NSCs) | - |
dc.subject.local | Notch | - |
dc.subject.local | PINK1 | - |
dc.description.journalClass | Y | - |
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