Aralia cordata inhibits triacylglycerol biosynthesis in HepG2 cells

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dc.contributor.authorMun-Ock Kim-
dc.contributor.authorS H Lee-
dc.contributor.authorJ H Seo-
dc.contributor.authorI S Kim-
dc.contributor.authorAh Reum Han-
dc.contributor.authorD O Moon-
dc.contributor.authorSungchan Cho-
dc.contributor.authorL Cui-
dc.contributor.authorJ Kim-
dc.contributor.authorHyun Sun Lee-
dc.date.accessioned2017-04-19T09:49:43Z-
dc.date.available2017-04-19T09:49:43Z-
dc.date.issued2013-
dc.identifier.issn1096620X-
dc.identifier.uri10.1089/jmf.2012.2636ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11777-
dc.description.abstractGlycerol-3-phosphate acyltransferase (GPAT) catalyzes the first committed step in triacylglycerol (TAG) and phospholipid biosynthesis, and has been considered as one of the drug targets for treating hepatic steatosis, insulin resistance, and other metabolic disorders. The aim of this study was to investigate the GPAT inhibitors from natural products and to evaluate their effects. The methanol extract of Aralia cordata roots showed a strong inhibitory effect on the human GPAT1 activity. A further bioactivity-guided approach led to the isolation of ent-pimara-8(14),15-dien-19-oic acid, (PA), one of the major compounds of A. cordata, which suppressed the GPAT1 activity with IC 50 value of 60.5 μM. PA markedly reduced de novo lysophosphatidic acid synthesis through inhibition of GPAT activity and therefore significantly decreased synthesis of TAG in the HepG2 cells. These results suggest that PA as well as A. cordata root extract could be beneficial in controlling lipid metabolism.-
dc.publisherMary Ann Liebert, Inc-
dc.titleAralia cordata inhibits triacylglycerol biosynthesis in HepG2 cells-
dc.title.alternativeAralia cordata inhibits triacylglycerol biosynthesis in HepG2 cells-
dc.typeArticle-
dc.citation.titleJournal of Medicinal Food-
dc.citation.number12-
dc.citation.endPage1114-
dc.citation.startPage1108-
dc.citation.volume16-
dc.contributor.affiliatedAuthorMun-Ock Kim-
dc.contributor.affiliatedAuthorSungchan Cho-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.alternativeName김문옥-
dc.contributor.alternativeName이선화-
dc.contributor.alternativeName서지희-
dc.contributor.alternativeName김일순-
dc.contributor.alternativeName한아름-
dc.contributor.alternativeName문동오-
dc.contributor.alternativeName조성찬-
dc.contributor.alternativeNameCui-
dc.contributor.alternativeName김정우-
dc.contributor.alternativeName이현선-
dc.identifier.bibliographicCitationJournal of Medicinal Food, vol. 16, no. 12, pp. 1108-1114-
dc.identifier.doi10.1089/jmf.2012.2636-
dc.subject.keywordAralia cordata-
dc.subject.keywordEnt-pimara-8(14),15-dien-19-oic acid-
dc.subject.keywordGlycerol-3-phosphate acyltransferase-
dc.subject.keywordLysophophatidic acid-
dc.subject.keywordTriacylglycerol-
dc.subject.localAralia cordata-
dc.subject.localEnt-pimara-8(14),15-dien-19-oic acid-
dc.subject.localGlycerol-3-phosphate acyltransferase-
dc.subject.localGlycerol-3-phosphate acyl transferase (GPAT)-
dc.subject.localLysophophatidic acid-
dc.subject.localTriacylglycerol-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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