Oleanolic acid acetate inhibits osteoclast differentiation by downregulating PLCgamma2-Ca2+-NFATc1 signaling, and suppresses bone loss in mice = 파골세포 분화와 마우스에서 골파괴를 억제하는 올레놀린산

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dc.contributor.authorJ Y Kim-
dc.contributor.authorY H Cheon-
dc.contributor.authorHyun-Mee Oh-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorM Erkhembaatar-
dc.contributor.authorM S Kim-
dc.contributor.authorC H Lee-
dc.contributor.authorJ J Kim-
dc.contributor.authorM K Choi-
dc.contributor.authorK H Yoon-
dc.contributor.authorM S Lee-
dc.contributor.authorJ Oh-
dc.date.accessioned2017-04-19T09:49:43Z-
dc.date.available2017-04-19T09:49:43Z-
dc.date.issued2014-
dc.identifier.issn87563282-
dc.identifier.uri10.1016/j.bone.2013.12.013ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11779-
dc.description.abstractOwing to their potential pharmacological activities in human disease, natural plant-derived compounds have recently become the focus of increased research interest. In this study, we first isolated oleanolic acid acetate (OAA), a triterpenoid compound, from Vigna angularis (azuki bean) to discover anti-bone resorptive agents. Many studies have identified and described the various medicinal effects of V. angularis extract. However, the pharmacological effect of OAA-derived V. angularis extract, particularly the effect on osteoclastogenesis, is not known. Therefore, we investigated the effect and mechanism of OAA in receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis. OAA inhibited RANKL-induced osteoclast differentiation in bone marrow macrophages (BMMs) without any evidence of cytotoxicity. Interestingly, OAA significantly inhibited Btk phosphorylation, phospholipase Cγ2 (PLCγ2) phosphorylation, calcium ion (Ca2+) oscillation, and nuclear factor of activated T cell c1 (NFATc1) expression in RANKL-stimulated BMMs, but did not affect RANKL-induced mitogen-activated protein kinase. OAA also inhibited the bone-resorbing activity of mature osteoclasts. Furthermore, mice treated with OAA demonstrated marked attenuation of lipopolysaccharide-induced bone erosion based on micro-computed tomography and histologic analysis of femurs. Taken together, the results suggested that OAA inhibited RANKL-mediated osteoclastogenesis via PLCγ2-Ca2+-NFATc1 signaling in vitro and suppressed inflammatory bone loss in vivo-
dc.publisherElsevier-
dc.titleOleanolic acid acetate inhibits osteoclast differentiation by downregulating PLCgamma2-Ca2+-NFATc1 signaling, and suppresses bone loss in mice = 파골세포 분화와 마우스에서 골파괴를 억제하는 올레놀린산-
dc.title.alternativeOleanolic acid acetate inhibits osteoclast differentiation by downregulating PLCgamma2-Ca2+-NFATc1 signaling, and suppresses bone loss in mice-
dc.typeArticle-
dc.citation.titleBone-
dc.citation.number0-
dc.citation.endPage111-
dc.citation.startPage104-
dc.citation.volume60-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeName김주영-
dc.contributor.alternativeName천윤희-
dc.contributor.alternativeName오현미-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeNameErkhembaatar-
dc.contributor.alternativeName김민석-
dc.contributor.alternativeName이창훈-
dc.contributor.alternativeName김정중-
dc.contributor.alternativeName최민규-
dc.contributor.alternativeName윤권하-
dc.contributor.alternativeName이명수-
dc.contributor.alternativeName오재민-
dc.identifier.bibliographicCitationBone, vol. 60, pp. 104-111-
dc.identifier.doi10.1016/j.bone.2013.12.013-
dc.subject.keywordCalcium oscillation-
dc.subject.keywordNFATc1-
dc.subject.keywordOleanolic acid acetate-
dc.subject.keywordOsteoclast-
dc.subject.keywordPLCγ2-
dc.subject.localCalcium oscillation-
dc.subject.localNFATc1-
dc.subject.localNF-ATc1-
dc.subject.localOleanolic acid acetate-
dc.subject.localOsteoclast-
dc.subject.localPLCγ2-
dc.subject.localPLC-γ2-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
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