Ginsenoside Rb1 is transformed into Rd and Rh2 by Microbacterium trichothecenolyticum

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Title
Ginsenoside Rb1 is transformed into Rd and Rh2 by Microbacterium trichothecenolyticum
Author(s)
H Kim; J H Kim; Phil Young Lee; Kwang-Hee Bae; S Cho; Byoung Chul Park; H Shin; Sung Goo Park
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 23, no. 12, pp. 1802-1805
Publication Year
2013
Abstract
Ginsenosides are the most important ingredient of ginseng and are known to possess many pharmacological and biological effects. Rb1, a major protopanaxadiol ginsenoside, is the most abundant ginsenoside in Panax ginseng C.A Meyer and can be hydrolyzed into more pharmaceutically potent minor ginsenosides. To identify a microorganism that is capable of converting Rb1 into other ginsenosides, we screened 12 Microbacterium spp., and M. trichothecenolyticum was identified as a likely candidate. M. trichothecenolyticum converted Rb1 into Rd and then into Rh2 based on TLC and HPLC analyses of reaction products. This biotransformation method can be easily applied for mass production of Rd and Rh2 by using Rb1.
Keyword
BiotransformationGinsenosideMicrobacteriumTLC
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4014/jmb.1307.07049
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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