Chitosan-based intelligent theragnosis nanocomposites enable pH-sensitive drug release with MR-guided imaging for cancer therapy

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dc.contributor.authorEun Kyung Lim-
dc.contributor.authorW Sajomsang-
dc.contributor.authorY Choi-
dc.contributor.authorE Jang-
dc.contributor.authorH Lee-
dc.contributor.authorB Kang-
dc.contributor.authorE Kim-
dc.contributor.authorS Haam-
dc.contributor.authorJ S Suh-
dc.contributor.authorSang Jeon Chung-
dc.contributor.authorY M Huh-
dc.date.accessioned2017-04-19T09:50:24Z-
dc.date.available2017-04-19T09:50:24Z-
dc.date.issued2013-
dc.identifier.issn19317573-
dc.identifier.uri10.1186/1556-276X-8-467ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11796-
dc.description.abstractSmart drug delivery systems that are triggered by environmental conditions have been developed to enhance cancer therapeutic efficacy while limiting unwanted effects. Because cancer exhibits abnormally high local acidities compared to normal tissues (pH 7.4) due to Warburg effects, pH-sensitive systems have been researched for effective cancer therapy. Chitosan-based intelligent theragnosis nanocomposites, N-naphthyl-O-dimethymaleoyl chitosan-based drug-loaded magnetic nanoparticles (NChitosan-DMNPs), were developed in this study. NChitosan-DMNPs are capable of pH-sensitive drug release with MR-guided images because doxorubicin (DOX) and magnetic nanocrystals (MNCs) are encapsulated into the designed N-naphthyl-O-dimethymaleoyl chitosan (N-nap-O-MalCS). This system exhibits rapid DOX release as acidity increases, high stability under high pH conditions, and sufficient capacity for diagnosing and monitoring therapeutic responses. These results demonstrate that NChitosan-DMNPs have potential as theragnosis nanocomposites for effective cancer therapy.-
dc.publisherSpringer-
dc.titleChitosan-based intelligent theragnosis nanocomposites enable pH-sensitive drug release with MR-guided imaging for cancer therapy-
dc.title.alternativeChitosan-based intelligent theragnosis nanocomposites enable pH-sensitive drug release with MR-guided imaging for cancer therapy-
dc.typeArticle-
dc.citation.titleNanoscale Research Letters-
dc.citation.number0-
dc.citation.endPage467-
dc.citation.startPage467-
dc.citation.volume8-
dc.contributor.affiliatedAuthorEun Kyung Lim-
dc.contributor.alternativeName임은경-
dc.contributor.alternativeNameSajomsang-
dc.contributor.alternativeName최윤아-
dc.contributor.alternativeName장은지-
dc.contributor.alternativeName이현재-
dc.contributor.alternativeName강병훈-
dc.contributor.alternativeName김은정-
dc.contributor.alternativeName함승주-
dc.contributor.alternativeName서진석-
dc.contributor.alternativeName정상전-
dc.contributor.alternativeName허용민-
dc.identifier.bibliographicCitationNanoscale Research Letters, vol. 8, pp. 467-467-
dc.identifier.doi10.1186/1556-276X-8-467-
dc.subject.keywordCancer therapy-
dc.subject.keywordDrug delivery-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordNanocomposites-
dc.subject.keywordpH-sensitive-
dc.subject.keywordTheragnosis-
dc.subject.localCancer therapy-
dc.subject.localDrug delivery-
dc.subject.localMagnetic resonance imaging-
dc.subject.localMagnetic resonance imaging (MRI)-
dc.subject.localNanocomposites-
dc.subject.localNanocomposite-
dc.subject.localpH-sensitive-
dc.subject.localTheragnosis-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
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