Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor SMILE
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- Title
- Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor SMILE
- Author(s)
- J M Lee; Gil Tae Gang; D K Kim; Y D Kim; S H Koo; Chul Ho Lee; H S Choi
- Bibliographic Citation
- Journal of Biological Chemistry, vol. 289, no. 2, pp. 1079-1091
- Publication Year
- 2014
- Abstract
- Background: Small heterodimer partner interacting leucine zipper protein (SMILE) is a nuclear corepressor of the nuclear receptor family. Results: Ursodeoxycholic acid (UDCA) increases SMILE gene expression, which contributes to inhibiting liver X receptor α (LXRα)-mediated hepatic lipogenesis. Conclusion: UDCA-induced smile inhibits LXRα-mediated hepatic lipogenic gene expression.
- ISSN
- 0021-9258
- Publisher
- Amer Soc Biochemistry Molecular Biology Inc
- Full Text Link
- http://dx.doi.org/10.1074/jbc.M113.491522
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > 1. Journal Articles
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