Metabolite changes signal genetic regulatory mechanisms for robust cell behavior

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dc.contributor.authorSang Jun Lee-
dc.contributor.authorA Trostel-
dc.contributor.authorS Adhya-
dc.date.accessioned2017-04-19T09:50:36Z-
dc.date.available2017-04-19T09:50:36Z-
dc.date.issued2014-
dc.identifier.issn2150-7511-
dc.identifier.uri10.1128/mBio.00972-13ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11810-
dc.description.abstractExploiting mechanisms of utilizing the sugar D-galactose in Escherichia coli as a model system, we explored the consequences of accumulation of critical intermediates of the D-galactose metabolic pathways by monitoring cell growth, metabolites, and transcript profiles. These studies revealed both metabolic network changes far from the D-galactose pathway and changes in the global gene regulatory network. The concentration change of a critical intermediate disturbs the equilibrium state, generating a ripple effect through several metabolic pathways that ends up signaling up- or downregulation of specific sets of genes in a programmed manner to cope with the imbalance. Such long-range effects on metabolites and genetic regulatory mechanisms not only may be a common feature in bacteria but very likely operate during cellular development and differentiation in higher organisms as well as in disease cells, like cancer cells-
dc.publisherAmer Soc Microb-
dc.titleMetabolite changes signal genetic regulatory mechanisms for robust cell behavior-
dc.title.alternativeMetabolite changes signal genetic regulatory mechanisms for robust cell behavior-
dc.typeArticle-
dc.citation.titleMbio-
dc.citation.number1-
dc.citation.endPagee00972-
dc.citation.startPagee00972-
dc.citation.volume5-
dc.contributor.affiliatedAuthorSang Jun Lee-
dc.contributor.alternativeName이상준-
dc.contributor.alternativeNameTrostel-
dc.contributor.alternativeNameAdhya-
dc.identifier.bibliographicCitationMbio, vol. 5, no. 1, pp. e00972-e00972-
dc.identifier.doi10.1128/mBio.00972-13-
dc.description.journalClassY-
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