Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells

Cited 0 time in scopus
Metadata Downloads
Title
Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells
Author(s)
Anna Park; Won Kon-KimKwang-Hee Bae
Bibliographic Citation
World Journal of Stem Cells, vol. 6, no. 1, pp. 33-42
Publication Year
2014
Abstract
Adipose tissue is a major metabolic organ, and it has been traditionally classified as either white adipose tissue (WAT) or brown adipose tissue (BAT). WAT and BAT are characterized by different anatomical locations, morphological structures, functions, and regulations. WAT and BAT are both involved in energy balance. WAT is mainly involved in the storage and mobilization of energy in the form of triglycerides, whereas BAT specializes in dissipating energy as heat during cold- or diet-induced thermogenesis. Recently, brownlike adipocytes were discovered in WAT. These brownlike adipocytes that appear in WAT are called beige or brite adipocytes. Interestingly, these beige/brite cells resemble white fat cells in the basal state, but they respond to thermogenic stimuli with increased levels of thermogenic genes and increased respiration rates. In addition, beige/brite cells have a gene expression pattern distinct from that of either white or brown fat cells. The current epidemic of obesity has increased the interest in studying adipocyte formation (adipogenesis), especially in beige/brite cells. This review summarizes the developmental process of adipose tissues that originate from the mesenchymal stem cells and the features of these three different types of adipocytes.
Keyword
White adipocytesBrown adipocytesBeige/brite adipocytesMesenchymal stem cellsAdipogenesisThermogenesisBrowning
ISSN
1948-0210
Publisher
Baishideng Publishing Group Inc
DOI
http://dx.doi.org/10.4252/wjsc.v6.i1.33
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.