Low-dose-rate radiation exposure leads to testicular damage with decreases in DNMT1 and HDAC1 in the murine testis

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dc.contributor.authorE J Gong-
dc.contributor.authorIn Sik Shin-
dc.contributor.authorT G Son-
dc.contributor.authorK Yang-
dc.contributor.authorK Heo-
dc.contributor.authorJ S Kim-
dc.date.accessioned2017-04-19T09:51:01Z-
dc.date.available2017-04-19T09:51:01Z-
dc.date.issued2014-
dc.identifier.issn0449-3060-
dc.identifier.uri10.1093/jrr/rrt090ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11833-
dc.description.abstractThis study examined the effects of continuous low-dose-rate radiation exposure (3.49 mGy/h) of gamma rays on mice testicles. C57BL/6 mice were divided into sham and radiation groups (n = 8 each), and were exposed to either sham irradiation or 2 Gy for 21 days, 0.2 Gy for 2 days, or 0.02 Gy for 6 h of low-dose-rate irradiation. Testicular weight, seminiferous tubular diameter, and seminiferous epithelial depth were significantly decreased in the mice irradiated with 2 Gy at 1 and 9 days after exposure. Moreover, the low-dose-rate radiation exposure induced an increase in malondialdehyde levels, and a decrease in superoxide dismutase activity in the testis of mice irradiated with 2 Gy at 1 and 9 days after exposure. The sperm count and motility in the epididymis also decreased in mice irradiated with 2 Gy at 1 and 9 days after exposure, whereas there was no significant effect on the proportion of abnormal sperm. The expressions of DNA methlytransferases-1 and histone deacetylases 1 in testes irradiated with 2 Gy were significantly decreased compared with the sham group. In conclusion, the damage exerted on the testes and epididymis largely depended on the total dose of low-dose-rate radiation.-
dc.publisherOxford Univ Press-
dc.titleLow-dose-rate radiation exposure leads to testicular damage with decreases in DNMT1 and HDAC1 in the murine testis-
dc.title.alternativeLow-dose-rate radiation exposure leads to testicular damage with decreases in DNMT1 and HDAC1 in the murine testis-
dc.typeArticle-
dc.citation.titleJournal of Radiation Research-
dc.citation.number1-
dc.citation.endPage60-
dc.citation.startPage54-
dc.citation.volume55-
dc.contributor.affiliatedAuthorIn Sik Shin-
dc.contributor.alternativeName공은지-
dc.contributor.alternativeName신인식-
dc.contributor.alternativeName손태진-
dc.contributor.alternativeName양광모-
dc.contributor.alternativeName허규-
dc.contributor.alternativeName김중선-
dc.identifier.bibliographicCitationJournal of Radiation Research, vol. 55, no. 1, pp. 54-60-
dc.identifier.doi10.1093/jrr/rrt090-
dc.subject.keywordlow-dose-rate radiation-
dc.subject.keywordradiation effects-
dc.subject.keywordsperm-
dc.subject.keywordtestis-
dc.subject.locallow-dose-rate radiation-
dc.subject.localradiation effects-
dc.subject.localSperm-
dc.subject.localsperm-
dc.subject.localTestis-
dc.subject.localtestis-
dc.subject.localTestes-
dc.description.journalClassY-
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