PHLPP1 regulates contact inhibition by dephosphorylating Mst1 at the inhibitory site

Cited 7 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorS Jung-
dc.contributor.authorJeong Gu Kang-
dc.contributor.authorJu Hee Lee-
dc.contributor.authorKyoung Jin Song-
dc.contributor.authorJeong Heon Ko-
dc.contributor.authorYong Sam Kim-
dc.date.accessioned2017-04-19T09:51:14Z-
dc.date.available2017-04-19T09:51:14Z-
dc.date.issued2014-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2013.12.129ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11857-
dc.description.abstractContact inhibition has been largely elusive despite that a loss of contact inhibition is a critical event for cancer development and progression. Here, we report that PHLPP1 is a binding protein for Mst1 and it modulates the Hippo pathway by dephosphorylating Mst1 at the inhibitory Thr387 of Mst1. Yap1 was localized predominantly in the nucleus but marginally in the cytoplasm in HeLa cells under sparse conditions, whereas the functional protein was more directed to sequestration in the cytoplasm under dense environments. Furthermore, loss of PHLPP1 resulted in a failure of the apoptotic control. It is interesting that down-regulated expression of PHLPP1 appears to mimic the loss of contact inhibition, a hallmark of cancer.-
dc.publisherElsevier-
dc.titlePHLPP1 regulates contact inhibition by dephosphorylating Mst1 at the inhibitory site-
dc.title.alternativePHLPP1 regulates contact inhibition by dephosphorylating Mst1 at the inhibitory site-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number4-
dc.citation.endPage1269-
dc.citation.startPage1263-
dc.citation.volume443-
dc.contributor.affiliatedAuthorJeong Gu Kang-
dc.contributor.affiliatedAuthorJu Hee Lee-
dc.contributor.affiliatedAuthorKyoung Jin Song-
dc.contributor.affiliatedAuthorJeong Heon Ko-
dc.contributor.affiliatedAuthorYong Sam Kim-
dc.contributor.alternativeName정수진-
dc.contributor.alternativeName강정구-
dc.contributor.alternativeName이주희-
dc.contributor.alternativeName송경진-
dc.contributor.alternativeName고정헌-
dc.contributor.alternativeName김용삼-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 443, no. 4, pp. 1263-1269-
dc.identifier.doi10.1016/j.bbrc.2013.12.129-
dc.subject.keywordContact inhibition-
dc.subject.keywordHippo pathway-
dc.subject.keywordMst1-
dc.subject.keywordPHLPP1-
dc.subject.localContact inhibition-
dc.subject.localHippo pathway-
dc.subject.localMst1-
dc.subject.localPHLPP1-
dc.description.journalClassY-
Appears in Collections:
Synthetic Biology and Bioengineering Research Institute > Genome Editing Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.