Anti-inflammatory activity of a methanol extract from Ardisia tinctoria on mouse macrophages and paw edema = 알디시아 팅크토리아의 항염효과

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Title
Anti-inflammatory activity of a methanol extract from Ardisia tinctoria on mouse macrophages and paw edema = 알디시아 팅크토리아의 항염효과
Author(s)
Hui Seong Kim; Ji Won Park; Ok-Kyoung Kwon; J H Kim; Sei-Ryang Oh; Hyeong Kyu Lee; T T Bach; B H Quang; Kyung Seop Ahn
Bibliographic Citation
Molecular Medicine Reports, vol. 9, no. 4, pp. 1388-1394
Publication Year
2014
Abstract
Ardisia tinctoria (AT) is a plant of the Myrsinaceae family. No studies on its anti-inflammatory effects have yet been reported. This study investigated the anti-inflammatory activity of AT. A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to significantly reduced levels of nitric oxide (NO) and prostaglandin E2 ( PGE2) and of two proteins regulated by these, interleukin-1β (IL-1β) and IL-6, in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The thickness of paw edema induced in vivo in mice by carrageenan administration was effectively reduced by the AT extract. Translocation of the nuclear factor-kappa;B (NF-kappa;B) subunit 65 (p65) into the nucleus and phosphorylation of mitogen-activated protein kinase kinase (MEK) and extracellular signal-related kinase (ERK) were inhibited by the AT extract. Our results indicated that a methanol extract of AT downregulates the inflammatory response by blocking phosphorylation of MEK and ERK and activation of NF-kappa;B. To the best of our knowledge, this is the first study of anti-inflammatory effects of an AT extract, and demonstrates its potential in the treatment of inflammatory diseases.
Keyword
Ardisia tinctoriaInflammationMAPKNF-κBNitric oxid
ISSN
1791-2997
Publisher
Spandidos Publ Ltd
DOI
http://dx.doi.org/10.3892/mmr.2014.1941
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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