Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system

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dc.contributor.authorK E Lee-
dc.contributor.authorJihae Seo-
dc.contributor.authorJ Shin-
dc.contributor.authorE H Ji-
dc.contributor.authorJ Roh-
dc.contributor.authorJ Y Kim-
dc.contributor.authorW Sun-
dc.contributor.authorJ Muhr-
dc.contributor.authorS Lee-
dc.contributor.authorJ Kim-
dc.date.accessioned2017-04-19T09:51:15Z-
dc.date.available2017-04-19T09:51:15Z-
dc.date.issued2014-
dc.identifier.issn0027-8424-
dc.identifier.uri10.1073/pnas.1308758111ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11861-
dc.description.abstractHow a pool of undifferentiated neural progenitor cells is maintained in the developing nervous system is an issue that remains unresolved. One of the key transcription factors for self-renewal of these cells is Sox2, the forced expression of which has been shown to inhibit neuronal differentiation in vivo. To dissect the molecular mechanisms of Sox2 activity, a ChIP-on-chip assay has been carried out for Sox2, and multiple candidate direct target genes have been isolated. In this report, we provide evidence indicating that Sox6, which like Sox2 belongs to the SRY-related HMG box transcription factor family, is a bona-fide direct regulatory target of Sox2. In vivo, Sox6 expression is seen with a temporal lag in Sox2-positive neural precursor cells in the ventricular zone, and Sox2 promotes expression of Sox6 as a transcriptional activator. Interestingly, gain- and loss-of-function assays indicate that Sox6 in turn is required for the maintenance of Sox2 expression, suggesting that a positive feedback loop, which functions to inhibit premature neuronal differentiation, exists between the two transcription factors.-
dc.publisherNatl Acad Sciences-
dc.titlePositive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system-
dc.title.alternativePositive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system-
dc.typeArticle-
dc.citation.titleProceedings of National Academy of Sciences of United States of America-
dc.citation.number7-
dc.citation.endPage2799-
dc.citation.startPage2794-
dc.citation.volume111-
dc.contributor.affiliatedAuthorJihae Seo-
dc.contributor.alternativeName이경은-
dc.contributor.alternativeName서지혜-
dc.contributor.alternativeName신지헌-
dc.contributor.alternativeName지은혜-
dc.contributor.alternativeName노지원-
dc.contributor.alternativeName김주연-
dc.contributor.alternativeName선웅-
dc.contributor.alternativeNameMuhr-
dc.contributor.alternativeName이상혁-
dc.contributor.alternativeName김재상-
dc.identifier.bibliographicCitationProceedings of National Academy of Sciences of United States of America, vol. 111, no. 7, pp. 2794-2799-
dc.identifier.doi10.1073/pnas.1308758111-
dc.subject.keywordCNS-
dc.subject.keywordNeural development-
dc.subject.keywordNeural stem cell-
dc.subject.keywordSoxB1-
dc.subject.keywordSoxD-
dc.subject.localCNS-
dc.subject.localNeural Development-
dc.subject.localneural development-
dc.subject.localNeural development-
dc.subject.localneural stem cell-
dc.subject.localNeural stem cell-
dc.subject.localNeural stem cells-
dc.subject.localNeural stem cells (NSCs)-
dc.subject.localSoxB1-
dc.subject.localSoxD-
dc.description.journalClassY-
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