2-Cys peroxiredoxins: Emerging hubs determining redox dependency of mammalian signaling networks

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dc.contributor.authorJinah Park-
dc.contributor.authorS Lee-
dc.contributor.authorS Lee-
dc.contributor.authorS W Kang-
dc.date.accessioned2017-04-19T09:51:25Z-
dc.date.available2017-04-19T09:51:25Z-
dc.date.issued2014-
dc.identifier.issn1687-8876-
dc.identifier.uri10.1155/2014/715867ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11872-
dc.description.abstractMammalian cells have a well-defined set of antioxidant enzymes, which includes superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins. Peroxiredoxins are the most recently identified family of antioxidant enzymes that catalyze the reduction reaction of peroxides, such as H2O2. In particular, typical 2-Cys peroxiredoxins are the featured peroxidase enzymes that receive the electrons from NADPH by coupling with thioredoxin and thioredoxin reductase. These enzymes distribute throughout the cellular compartments and, therefore, are thought to be broad-range antioxidant defenders. However, recent evidence demonstrates that typical 2-Cys peroxiredoxins play key signal regulatory roles in the various signaling networks by interacting with or residing near a specific redox-sensitive molecule. These discoveries help reveal the redox signaling landscape in mammalian cells and may further provide a new paradigm of therapeutic approaches based on redox signaling.-
dc.publisherHindawi Publishing Corporationko
dc.title2-Cys peroxiredoxins: Emerging hubs determining redox dependency of mammalian signaling networks-
dc.title.alternative2-Cys peroxiredoxins: Emerging hubs determining redox dependency of mammalian signaling networks-
dc.typeArticle-
dc.citation.titleInternational Journal of Cell Biology-
dc.citation.number0-
dc.citation.endPage715867-
dc.citation.startPage715867-
dc.citation.volume2014-
dc.contributor.affiliatedAuthorJinah Park-
dc.contributor.alternativeName박진아-
dc.contributor.alternativeName이선미-
dc.contributor.alternativeName이상혁-
dc.contributor.alternativeName강상원-
dc.identifier.bibliographicCitationInternational Journal of Cell Biology, vol. 2014, pp. 715867-715867-
dc.identifier.doi10.1155/2014/715867-
dc.description.journalClassN-
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