Anti-inflammatory and anti-oxidative effects of the ethanol extract of Cryptocarya densiflora blume in lipopolysaccharide-stimulated RAW264.7 mouse macrophages = 크립토카랴 덴시플로라의 항염 및 항산화 효과

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dc.contributor.authorJi Won Park-
dc.contributor.authorOk-Kyoung Kwon-
dc.contributor.authorDoo-Young Kim-
dc.contributor.authorJung Hee Kim-
dc.contributor.authorIn Sik Shin-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorS W Lee-
dc.contributor.authorJ H Kim-
dc.contributor.authorH Jin-
dc.contributor.authorW Y Lee-
dc.contributor.authorKyung Seop Ahn-
dc.date.accessioned2017-04-19T09:51:42Z-
dc.date.available2017-04-19T09:51:42Z-
dc.date.issued2014-
dc.identifier.issn2328-2150-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11881-
dc.description.abstractEcklonia stolonifera is a brown alga that was shown to have antioxidant, anti-inflammatory, tyrosinase inhibitory, and chemopreventive activities. However, the molecular mechanisms underlying its anti-inflammatory activity remain unclear. In this study, we investigated the molecular mechanism of the anti-inflammatory action of E. stolonifera ethanolic extracts (ESE) using lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. ESE inhibited LPS-induced nitric oxide (IC50 = 72 ± 1.9 μg/mL) and prostaglandin E2 (IC50 = 98 ± 5.3 μg/mL) production in a dose-dependent manner and suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 cells. ESE also reduced the production of pro-inflammatory cytokines in LPS-stimulated RAW 264.7 cells. LPS-induced nuclear factor-κB (NF-κB) transcriptional activity and NF-κB translocation into the nucleus were significantly inhibited by ESE treatment through the prevention of the degradation of inhibitor κB-α. Moreover, ESE inhibited the activation of Akt, ERK, JNK1/2, and p38 MAPK in LPS-stimulated RAW 264.7 cells. The main components with anti-inflammatory activity in ESE were identified as phlorofucofuroeckol A and B based on the inhibition of NO production. Our results indicate that ESE can be considered as a potential source of therapeutic agents for inflammatory diseases.-
dc.titleAnti-inflammatory and anti-oxidative effects of the ethanol extract of Cryptocarya densiflora blume in lipopolysaccharide-stimulated RAW264.7 mouse macrophages = 크립토카랴 덴시플로라의 항염 및 항산화 효과-
dc.title.alternativeAnti-inflammatory and anti-oxidative effects of the ethanol extract of Cryptocarya densiflora blume in lipopolysaccharide-stimulated RAW264.7 mouse macrophages-
dc.typeArticle-
dc.citation.titleJournal of Pharmacy and Pharmacology (David Publishing)-
dc.citation.number1-
dc.citation.endPage37-
dc.citation.startPage26-
dc.citation.volume2-
dc.contributor.affiliatedAuthorJi Won Park-
dc.contributor.affiliatedAuthorOk-Kyoung Kwon-
dc.contributor.affiliatedAuthorDoo-Young Kim-
dc.contributor.affiliatedAuthorJung Hee Kim-
dc.contributor.affiliatedAuthorIn Sik Shin-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.alternativeName박지원-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName김두영-
dc.contributor.alternativeName김정희-
dc.contributor.alternativeName신인식-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이상우-
dc.contributor.alternativeName김재홍-
dc.contributor.alternativeName진항-
dc.contributor.alternativeName이완이-
dc.contributor.alternativeName안경섭-
dc.identifier.bibliographicCitationJournal of Pharmacy and Pharmacology (David Publishing), vol. 2, no. 1, pp. 26-37-
dc.identifier.doi10.1021/jf3022018-
dc.subject.keywordanti-inflammation-
dc.subject.keywordEcklonia stolonifera-
dc.subject.keywordMAP kinases-
dc.subject.keywordNF-κB-
dc.subject.keywordRAW 264.7 cells-
dc.subject.localantiinflammation-
dc.subject.localAntiinflammation-
dc.subject.localanti-inflammation-
dc.subject.localAnti-Inflammation-
dc.subject.localAnti-inflammation-
dc.subject.localEcklonia stolonifera-
dc.subject.localMAP kinases-
dc.subject.localmap kinase-
dc.subject.localMAP kinase-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localRAW 264·7 cells-
dc.subject.localRAW 264.7 cells-
dc.description.journalClassN-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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