Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057

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Title
Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057
Author(s)
Mijin Oh; Jae-Hyuk Jang; S J Choo; Sun Ok Kim; Jong Won Kim; Sung-Kyun KoNak Kyun SoungJung-Sook Lee; Chang-Jin Kim; H Oh; Young-Soo Hong; M Ueki; H Hirota; H Osada; Bo Yeon KimJong Seog Ahn
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 24, no. 7, pp. 1802-1804
Publication Year
2014
Abstract
Three new pyrrolobenzodiazepine derivatives, boseongazepines A-C (1-3), were isolated from a culture broth of Streptomyces sp. 11A057, together with the known compound usabamycin B (4). The structures of 1-4 were determined through the analysis of spectroscopic data including extensive 1D-, 2D-NMR, and MS techniques. Cell growth inhibition effects of these compounds were evaluated against Jurkat, K-562, HL-60, and HepG2 cell lines.
Keyword
BoseongazepinesCytotoxicityPyrrolobenzodiazepineStreptomyces
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2014.02.022
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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