Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin

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Title
Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin
Author(s)
M J Kang; G S Ko; D G Oh; J S Kim; K Noh; W Kang; Woon Kee YoonHyoung-Chin Kim; H G Jeong; T C Jeong
Bibliographic Citation
Archives of Pharmacal Research, vol. 37, no. 3, pp. 371-378
Publication Year
2014
Abstract
Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in normal and antibiotic-pretreated rats following p.o. administration of 100 mg/kg baicalin by using liquid chromatography/ion trap mass spectrometry. When rats were pretreated orally with cefadroxil, oxytetracycline and erythromycin for 3 days to control the number of intestinal bacteria, the pharmacokinetic parameters of oral baicalin were significantly affected by antibiotics: Cmax, T1/2(β), K el and AUC values were significantly changed compared to those in normal rats. These results indicate that intestinal microbiota might play a key role in the oral pharmacokinetics of baicalin.
Keyword
BaicalinIntestinal bacteriaKineticsMetabolismRat
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-013-0179-2
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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