Rat lens aldose reductase inhibitory activities of Cissus assamica var. pilosissima and Syzygium oblatum

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Title
Rat lens aldose reductase inhibitory activities of Cissus assamica var. pilosissima and Syzygium oblatum
Author(s)
K H Lee; D G Lee; Sang Woo Lee; W Li; S Lee
Bibliographic Citation
Natural Products Sciences, vol. 19, no. 4, pp. 275-280
Publication Year
2013
Abstract
Aldose reductase (AR) has been shown to play an important role in the development of diabetic complications. To search for AR inhibitors from Chinese plants, the ethanol extracts of Chinese plants was tested against an inhibition of rat lens AR in vitro. Among Chinese plants tested, Cissus assamica var. pilosissima and Syzygium oblatum showed highest inhibition of AR (IC50 values, 0.71 and 0.79 μg/ml, respectively). Cissus assamica var. pilosissima and Syzygium oblatum showed more potent inhibitory activity against AR than the positive control, TMG. Consequently, C. assamica var. pilosissima and S. oblatum have a possibility of new natural resources for the development of AR inhibitor for the prevention of diabetic complications.
Keyword
Aldose reductaseChinese plantCissus assamica varDiabetic complicationsPilosissimaSyzygium oblatum
ISSN
I000-0147
Publisher
Korean Society of Pharmacognosy
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
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