Cited 0 time in
- Title
- Membrane proteins involved in epithelial-mesenchymal transition and tumor invasion: studies on TMPRSS4 and TM4SF5
- Author(s)
- Semi Kim; J W Lee
- Bibliographic Citation
- Genomics & Informatics, vol. 12, no. 1, pp. 12-20
- Publication Year
- 2014
- Abstract
- The epithelial-mesenchymal transition (EMT) is one mechanism by which cells with mesenchymal features can be generated and is a fundamental event in morphogenesis. Recently, invasion and metastasis of cancer cells from the primary tumor are now thought to be initiated by the developmental process termed the EMT, whereby epithelial cells lose cell polarity and cell-cell interactions, and gain mesenchymal phenotypes with increased migratory and invasive properties. The EMT is believed to be an important step in metastasis and is implicated in cancer progression, although the influence of the EMT in clinical specimens has been debated. This review presents the recent results of two cell surface proteins, the functions and underlying mechanisms of which have recently begun to be demonstrated, as novel regulators of the molecular networks that induce the EMT and cancer progression.
- Keyword
- TM4SF5TMPRSS4epithelial-mesenchymal transitioninvasionmembrane proteins
- ISSN
- I000-0158
- Publisher
- Korea Soc-Assoc-Inst
- DOI
- http://dx.doi.org/10.5808/GI.2014.12.1.12
- Type
- Article
- Appears in Collections:
- Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
- Files in This Item:
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.