Hepatoprotective effect of aged black garlic extract in rodents

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Title
Hepatoprotective effect of aged black garlic extract in rodents
Author(s)
Jung Hyu Shin; Chang Woo Lee; Soo Jin Oh; Ji Eun Yun; Moo Rim Kang; S B Han; H Park; J C Jung; Y H Chung; Jong Soon Kang
Bibliographic Citation
Toxicological Research, vol. 30, no. 1, pp. 49-54
Publication Year
2014
Abstract
In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.
Keyword
Aged black garlicCarbon tetrachlorideD-galactosamineLiver injuryNon-alcoholic fatty liver disease
ISSN
1976-8257
Publisher
South Korea
DOI
http://dx.doi.org/10.5487/TR.2014.30.1.049
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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