Structural modeling of Vpu from HIV-1 based on solid-state NMR observables

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dc.contributor.authorSeon Joo Ahn-
dc.contributor.authorGyu Tae Lim-
dc.contributor.authorS Nam-
dc.contributor.authorJinhyuk Lee-
dc.date.accessioned2017-04-19T09:52:47Z-
dc.date.available2017-04-19T09:52:47Z-
dc.date.issued2014-
dc.identifier.issn0009-2614-
dc.identifier.uri10.1016/j.cplett.2014.03.033ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11950-
dc.description.abstractVpu is one of the accessory proteins of HIV-1, and is involved in viral particle release. Viral particle release is enhanced by two proposed functions of Vpu: (i) tetherin interaction and (ii) membrane polarization. Two Vpu functions in viral particle release are still controversial. Here, we investigated the proposed functions by extensive structural modeling of Vpu based on solid-state NMR (Nuclear Magnetic Resonance) observables. We found that Vpu can co-exist in two structural forms: left-handed and right-handed conformation. The co-existence of the two conformations provides a clue to reconcile the controversial issue of its two functions in virus particle release.-
dc.publisherElsevier-
dc.titleStructural modeling of Vpu from HIV-1 based on solid-state NMR observables-
dc.title.alternativeStructural modeling of Vpu from HIV-1 based on solid-state NMR observables-
dc.typeArticle-
dc.citation.titleChemical Physics Letters-
dc.citation.number0-
dc.citation.endPage121-
dc.citation.startPage116-
dc.citation.volume599-
dc.contributor.affiliatedAuthorSeon Joo Ahn-
dc.contributor.affiliatedAuthorGyu Tae Lim-
dc.contributor.affiliatedAuthorJinhyuk Lee-
dc.contributor.alternativeName안선주-
dc.contributor.alternativeName임규태-
dc.contributor.alternativeName남승윤-
dc.contributor.alternativeName이진혁-
dc.identifier.bibliographicCitationChemical Physics Letters, vol. 599, pp. 116-121-
dc.identifier.doi10.1016/j.cplett.2014.03.033-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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