DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyung-En Yu | - |
dc.contributor.author | Soo Jin Oh | - |
dc.contributor.author | Je Kyung Ryu | - |
dc.contributor.author | Jong Soon Kang | - |
dc.contributor.author | J T Hong | - |
dc.contributor.author | J K Jung | - |
dc.contributor.author | S B Han | - |
dc.contributor.author | S Y Seo | - |
dc.contributor.author | Y H Kim | - |
dc.contributor.author | S K Park | - |
dc.contributor.author | H M Kim | - |
dc.contributor.author | K Lee | - |
dc.date.accessioned | 2017-04-19T09:52:48Z | - |
dc.date.available | 2017-04-19T09:52:48Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | 10.1002/ptr.5033 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11953 | - |
dc.description.abstract | The purpose of this study was to characterize the pharmacokinetics and metabolism of 4-O-methylhonokiol in rats. The absorption and disposition of 4-O-methylhonokiol were investigated in male Sprague-Dawley rats following a single intravenous (2 mg/kg) or oral (10 mg/kg) dose. Its metabolism was studied in vitro using rat liver microsomes and cytosol. 4-O-Methylhonokiol exhibited a high systemic plasma clearance and a large volume of distribution. The oral dose gave a peak plasma concentration of 24.1±3.3 ng/mL at 2.9±1.9 h and a low estimated bioavailability. 4-O-Methylhonokiol was rapidly metabolized and converted at least in part to honokiol in a concentration- dependent manner by cytochrome P450 in rat liver microsomes, predicting a high systemic clearance consistent with the pharmacokinetic results. It was also shown to be metabolized by glucuronidation and sulfation in rat liver microsomes and cytosol, respectively. 4-O-Methylhonokiol showed a moderate permeability with no apparent vectorial transport across Caco-2 cells, suggesting that intestinal permeation process is not likely to limit its oral absorption. Taken together, these results suggest that the rapid hepatic metabolism of 4-O-methylhonokiol could be the major reason for its high systemic clearance and low oral bioavailability. | - |
dc.publisher | Wiley | - |
dc.title | Pharmacokinetics and metabolism of 4-O-methylhonokiol in rats | - |
dc.title.alternative | Pharmacokinetics and metabolism of 4-O-methylhonokiol in rats | - |
dc.type | Article | - |
dc.citation.title | Phytotherapy Research | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 578 | - |
dc.citation.startPage | 568 | - |
dc.citation.volume | 28 | - |
dc.contributor.affiliatedAuthor | Hyung-En Yu | - |
dc.contributor.affiliatedAuthor | Soo Jin Oh | - |
dc.contributor.affiliatedAuthor | Je Kyung Ryu | - |
dc.contributor.affiliatedAuthor | Jong Soon Kang | - |
dc.contributor.alternativeName | 유형은 | - |
dc.contributor.alternativeName | 오수진 | - |
dc.contributor.alternativeName | 유제경 | - |
dc.contributor.alternativeName | 강종순 | - |
dc.contributor.alternativeName | 홍진태 | - |
dc.contributor.alternativeName | 정재경 | - |
dc.contributor.alternativeName | 한상배 | - |
dc.contributor.alternativeName | 서승용 | - |
dc.contributor.alternativeName | 김영휘 | - |
dc.contributor.alternativeName | 박성규 | - |
dc.contributor.alternativeName | 김환묵 | - |
dc.contributor.alternativeName | 이기호 | - |
dc.identifier.bibliographicCitation | Phytotherapy Research, vol. 28, no. 4, pp. 568-578 | - |
dc.identifier.doi | 10.1002/ptr.5033 | - |
dc.subject.keyword | 4-O-methylhonokiol | - |
dc.subject.keyword | honokiol | - |
dc.subject.keyword | metabolism | - |
dc.subject.keyword | neolignan | - |
dc.subject.keyword | pharmacokinetics | - |
dc.subject.local | 4-O-Methylhonokiol | - |
dc.subject.local | 4-O-methylhonokiol | - |
dc.subject.local | honokiol | - |
dc.subject.local | Honokiol | - |
dc.subject.local | metabolism | - |
dc.subject.local | Metabolism | - |
dc.subject.local | Neolignans | - |
dc.subject.local | Neo-lignan | - |
dc.subject.local | Neo-lignans | - |
dc.subject.local | neolignan | - |
dc.subject.local | Neolignan | - |
dc.subject.local | pharmacokinetics | - |
dc.subject.local | Pharmacokinetics | - |
dc.description.journalClass | Y | - |
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