Pharmacokinetics and metabolism of 4-O-methylhonokiol in rats

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dc.contributor.authorHyung-En Yu-
dc.contributor.authorSoo Jin Oh-
dc.contributor.authorJe Kyung Ryu-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorJ T Hong-
dc.contributor.authorJ K Jung-
dc.contributor.authorS B Han-
dc.contributor.authorS Y Seo-
dc.contributor.authorY H Kim-
dc.contributor.authorS K Park-
dc.contributor.authorH M Kim-
dc.contributor.authorK Lee-
dc.date.accessioned2017-04-19T09:52:48Z-
dc.date.available2017-04-19T09:52:48Z-
dc.date.issued2014-
dc.identifier.issn0951-418X-
dc.identifier.uri10.1002/ptr.5033ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11953-
dc.description.abstractThe purpose of this study was to characterize the pharmacokinetics and metabolism of 4-O-methylhonokiol in rats. The absorption and disposition of 4-O-methylhonokiol were investigated in male Sprague-Dawley rats following a single intravenous (2 mg/kg) or oral (10 mg/kg) dose. Its metabolism was studied in vitro using rat liver microsomes and cytosol. 4-O-Methylhonokiol exhibited a high systemic plasma clearance and a large volume of distribution. The oral dose gave a peak plasma concentration of 24.1±3.3 ng/mL at 2.9±1.9 h and a low estimated bioavailability. 4-O-Methylhonokiol was rapidly metabolized and converted at least in part to honokiol in a concentration- dependent manner by cytochrome P450 in rat liver microsomes, predicting a high systemic clearance consistent with the pharmacokinetic results. It was also shown to be metabolized by glucuronidation and sulfation in rat liver microsomes and cytosol, respectively. 4-O-Methylhonokiol showed a moderate permeability with no apparent vectorial transport across Caco-2 cells, suggesting that intestinal permeation process is not likely to limit its oral absorption. Taken together, these results suggest that the rapid hepatic metabolism of 4-O-methylhonokiol could be the major reason for its high systemic clearance and low oral bioavailability.-
dc.publisherWiley-
dc.titlePharmacokinetics and metabolism of 4-O-methylhonokiol in rats-
dc.title.alternativePharmacokinetics and metabolism of 4-O-methylhonokiol in rats-
dc.typeArticle-
dc.citation.titlePhytotherapy Research-
dc.citation.number4-
dc.citation.endPage578-
dc.citation.startPage568-
dc.citation.volume28-
dc.contributor.affiliatedAuthorHyung-En Yu-
dc.contributor.affiliatedAuthorSoo Jin Oh-
dc.contributor.affiliatedAuthorJe Kyung Ryu-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName유형은-
dc.contributor.alternativeName오수진-
dc.contributor.alternativeName유제경-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName홍진태-
dc.contributor.alternativeName정재경-
dc.contributor.alternativeName한상배-
dc.contributor.alternativeName서승용-
dc.contributor.alternativeName김영휘-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName이기호-
dc.identifier.bibliographicCitationPhytotherapy Research, vol. 28, no. 4, pp. 568-578-
dc.identifier.doi10.1002/ptr.5033-
dc.subject.keyword4-O-methylhonokiol-
dc.subject.keywordhonokiol-
dc.subject.keywordmetabolism-
dc.subject.keywordneolignan-
dc.subject.keywordpharmacokinetics-
dc.subject.local4-O-Methylhonokiol-
dc.subject.local4-O-methylhonokiol-
dc.subject.localhonokiol-
dc.subject.localHonokiol-
dc.subject.localmetabolism-
dc.subject.localMetabolism-
dc.subject.localNeolignans-
dc.subject.localNeo-lignan-
dc.subject.localNeo-lignans-
dc.subject.localneolignan-
dc.subject.localNeolignan-
dc.subject.localpharmacokinetics-
dc.subject.localPharmacokinetics-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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