Structural basis of sialidase in complex with geranylated flavonoids as potent natural inhibitors

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dc.contributor.authorY Lee-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorH S Youn-
dc.contributor.authorJ K Cho-
dc.contributor.authorYoung-Min Kim-
dc.contributor.authorJi Young Park-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorK H Park-
dc.contributor.authorS H Eom-
dc.date.accessioned2017-04-19T09:52:52Z-
dc.date.available2017-04-19T09:52:52Z-
dc.date.issued2014-
dc.identifier.citationActa Crystallographica. Section D, Biological Crystallography,70,5,1357,1365ko
dc.identifier.issn0907-4449-
dc.identifier.uri10.1107/S1399004714002971ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11961-
dc.description.abstractSialidase catalyzes the removal of a terminal sialic acid from glycoconjugates and plays a pivotal role in nutrition, cellular interactions and pathogenesis mediating various infectious diseases including cholera, influenza and sepsis. An array of antiviral sialidase agents have been developed and are commercially available, such as zanamivir and oseltamivir for treating influenza. However, the development of bacterial sialidase inhibitors has been much less successful. Here, natural polyphenolic geranylated flavonoids which show significant inhibitory effects against Cp-NanI, a sialidase from Clostridium perfringens, are reported. This bacterium causes various gastrointestinal diseases. The crystal structure of the Cp-NanI catalytic domain in complex with the best inhibitor, diplacone, is also presented. This structure explains how diplacone generates a stable enzyme-inhibitor complex. These results provide a structural framework for understanding the interaction between sialidase and natural flavonoids, which are promising scaffolds on which to discover new anti-sialidase agents.-
dc.publisherInt Union Crystallography-
dc.titleStructural basis of sialidase in complex with geranylated flavonoids as potent natural inhibitors-
dc.title.alternativeStructural basis of sialidase in complex with geranylated flavonoids as potent natural inhibitors-
dc.typeArticle-
dc.citation.titleActa Crystallographica Section D-Biological Crystallography-
dc.citation.number5-
dc.citation.endPage1365-
dc.citation.startPage1357-
dc.citation.volume70-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorYoung-Min Kim-
dc.contributor.affiliatedAuthorJi Young Park-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName이영진-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName윤형섭-
dc.contributor.alternativeName조정근-
dc.contributor.alternativeName김영민-
dc.contributor.alternativeName박지영-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName박기훈-
dc.contributor.alternativeName엄수현-
dc.identifier.bibliographicCitationActa Crystallographica Section D-Biological Crystallography, vol. 70, no. 5, pp. 1357-1365-
dc.identifier.doi10.1107/S1399004714002971-
dc.subject.keyworddiplacone-
dc.subject.keywordgeranylated flavonoid-
dc.subject.keywordNanI-
dc.subject.keywordsialidase-
dc.subject.keywordsialidase inhibitor-
dc.subject.localdiplacone-
dc.subject.localgeranylated flavonoid-
dc.subject.localNanI-
dc.subject.localsialidase-
dc.subject.localSialidase-
dc.subject.localsialidase inhibitor-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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