Diagnostic value of circulating extracellular miR-134, miR-185, and miR-22 levels in lung adenocarcinoma-associated malignant pleural effusion

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dc.contributor.authorY M Shin-
dc.contributor.authorJi Eun Yun-
dc.contributor.authorO J Lee-
dc.contributor.authorH S Han-
dc.contributor.authorS N Lim-
dc.contributor.authorJ Y An-
dc.contributor.authorK H Lee-
dc.contributor.authorK M Lee-
dc.contributor.authorK H Choe-
dc.date.accessioned2017-04-19T09:52:57Z-
dc.date.available2017-04-19T09:52:57Z-
dc.date.issued2014-
dc.identifier.issn1598-2998-
dc.identifier.uri10.4143/crt.2014.46.2.178ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11970-
dc.description.abstractPurpose The accurate and timely diagnosis of malignant pleural effusion (MPE) in lung cancer patients is important because MPE has a poor prognosis and is classified as stage IV disease. Molecular biomarkers for pleural effusion, such as circulating extracellular microRNAs (miRNAs) isolated from pleural fluid, may help in the diagnosis of MPE. The present study examined whether miRNAs that are deregulated in lung cancer (miR-134, miR-185, and miR-22) can serve as diagnostic markers for lung adenocarcinoma-associated MPE (LA-MPE). Materials and Methods Real-time reverse transcription quantitative polymerase chain reaction was used to measure the expression of the three miRNAs in samples from 87 patients with pleural effusion comprising 45 LA-MPEs and 42 benign pleural effusions (BPEs). The area under the receiver operating characteristic curve (AUC) was then used to evaluate the diagnostic performance of each of the three miRNAs and compare it with that of the common tumor marker, carcinoembryonic antigen (CEA). Results The expression of all three miRNAs was significantly lower in LA-MPE than in BPE (p <0.001). The AUCs for miR-134, miR-185, miR-22, and CEA were 0.721, 0.882, 0.832, and 0.898, respectively. Combining CEA with the three miRNAs increased the diagnostic performance, yielding an AUC of 0.942 (95% confidence interval, 0.864 to 0.982), with a sensitivity of 91.9% and a specificity of 92.5%. Conclusion The present study suggests that the expression levels of circulating extracellular miR-134, miR-185, and miR-22 in patients with pleural effusion may have diagnostic value when differentiating between LA-MPE and BPE.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleDiagnostic value of circulating extracellular miR-134, miR-185, and miR-22 levels in lung adenocarcinoma-associated malignant pleural effusion-
dc.title.alternativeDiagnostic value of circulating extracellular miR-134, miR-185, and miR-22 levels in lung adenocarcinoma-associated malignant pleural effusion-
dc.typeArticle-
dc.citation.titleCancer Research and Treatment-
dc.citation.number2-
dc.citation.endPage185-
dc.citation.startPage178-
dc.citation.volume46-
dc.contributor.affiliatedAuthorJi Eun Yun-
dc.contributor.alternativeName신윤미-
dc.contributor.alternativeName윤지은-
dc.contributor.alternativeName이옥준-
dc.contributor.alternativeName한혜숙-
dc.contributor.alternativeName임성남-
dc.contributor.alternativeName안진영-
dc.contributor.alternativeName이기형-
dc.contributor.alternativeName이기만-
dc.contributor.alternativeName최강현-
dc.identifier.bibliographicCitationCancer Research and Treatment, vol. 46, no. 2, pp. 178-185-
dc.identifier.doi10.4143/crt.2014.46.2.178-
dc.subject.keywordAdenocarcinoma-
dc.subject.keywordLung-
dc.subject.keywordmiR-134-
dc.subject.keywordmiR-185-
dc.subject.keywordmiR-22-
dc.subject.keywordPleural effusion-
dc.subject.localAdenocarcinoma-
dc.subject.locallung-
dc.subject.localLungs-
dc.subject.localLung-
dc.subject.localmiR-134-
dc.subject.localmiR-185-
dc.subject.localmiR-22-
dc.subject.localPleural effusion-
dc.subject.localpleural effusion-
dc.description.journalClassY-
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