Construction of artificial biosynthetic pathways for resveratrol glucoside derivatives = 당화 레스베라트롤 화합물 생합성 인공대사경로 구축

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Title
Construction of artificial biosynthetic pathways for resveratrol glucoside derivatives = 당화 레스베라트롤 화합물 생합성 인공대사경로 구축
Author(s)
Oksik Choi; Jae Kyoung Lee; Sun Young Kang; R P Pandey; J K Sohng; Jong Seog AhnYoung-Soo Hong
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 24, no. 5, pp. 614-618
Publication Year
2014
Abstract
Resveratrol, which is a polyphenolic antioxidant, is dose-dependent when used to provide health benefits, to enhance stress resistance, and to extend lifespans. However, even though resveratrol has therapeutic benefits, its clinical therapeutic effect is limited owing to its low oral bioavailability. An Escherichia coli system was developed that contains an artificial biosynthetic pathway that produces resveratrol glucoside derivatives, such as resveratrol-3-Oglucoside (piceid) and resveratrol-4'-O-glucoside (resveratroloside), from simple carbon sources. This artificial biosynthetic pathway contains a glycosyltransferase addition (YjiC from Bacillus) with resveratrol biosynthetic genes. The produced glucoside compounds were verified through the presence of a product peak(s) and also through LC/MS analyses. The strategy used in this research demonstrates the first harnessing of E. coli for de novo synthesis of resveratrol glucoside derivatives from a simple sugar medium.
Keyword
Artificial biosynthesisGlycosylationPiceidResveratrol
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4014/jmb.1401.01031
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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