Low-dose radiation suppresses pokemon expression under hypoxic conditions

Cited 2 time in scopus
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Title
Low-dose radiation suppresses pokemon expression under hypoxic conditions
Author(s)
S W Kim; Kweon YuKee Sun Shin; K Kwon; T S Hwang; O Y Kwon
Bibliographic Citation
Zeitschrift fur Naturforschung Section C-A Journal of Biosciences, vol. 69c, no. 1, pp. 68-74
Publication Year
2014
Abstract
Our previous data demonstrated that CoCl2-induced hypoxia controls endoplasmic reticulum (ER) stress-associated and other intracellular factors. One of them, the transcription factor Pokemon, was differentially regulated by low-dose radiation (LDR). There are limited data regarding how this transcription factor is involved in expression of the unfolded protein response (UPR) under hypoxic conditions. The purpose of this study was to obtain clues on how Pokemon is involved in the UPR. Pokemon was selected as a differentially expressed gene under hypoxic conditions; however, its regulation was clearly repressed by LDR. It was also demonstrated that both expression of ER chaperones and ER stress sensors were affected by hypoxic conditions, and the same results were obtained when cells in which Pokemon was up- or down-regulated were used. The current state of UPR and LDR research associated with the Pokemon pathway offers an important opportunity to understand the oncogenesis, senescence, and differentiation of cells, as well as to facilitate introduction of new therapeutic radiopharmaceuticals.
Keyword
HypoxiaLow-dose radiation (LDR)Pokemon
ISSN
0939-5075
Publisher
Walter De Gruyter Gmbh
DOI
http://dx.doi.org/10.5560/ZNC.2013-0035
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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