Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

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dc.contributor.authorEun Kyung Lim-
dc.contributor.authorB Kang-
dc.contributor.authorY Choi-
dc.contributor.authorE Jang-
dc.contributor.authorS Han-
dc.contributor.authorK Lee-
dc.contributor.authorJ S Suh-
dc.contributor.authorS Haam-
dc.contributor.authorY M Huh-
dc.date.accessioned2017-04-19T09:53:16Z-
dc.date.available2017-04-19T09:53:16Z-
dc.date.issued2014-
dc.identifier.issn0957-4484-
dc.identifier.uri10.1088/0957-4484/25/24/245103ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12003-
dc.description.abstractWe developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.-
dc.publisherIOP Publishing Ltd-
dc.titleGadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging-
dc.title.alternativeGadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging-
dc.typeArticle-
dc.citation.titleNanotechnology-
dc.citation.number24-
dc.citation.endPage245103-
dc.citation.startPage245103-
dc.citation.volume25-
dc.contributor.affiliatedAuthorEun Kyung Lim-
dc.contributor.alternativeName임은경-
dc.contributor.alternativeName강병훈-
dc.contributor.alternativeName최윤아-
dc.contributor.alternativeName장은지-
dc.contributor.alternativeName한승민-
dc.contributor.alternativeName이광열-
dc.contributor.alternativeName서진석-
dc.contributor.alternativeName함승주-
dc.contributor.alternativeName허용민-
dc.identifier.bibliographicCitationNanotechnology, vol. 25, no. 24, pp. 245103-245103-
dc.identifier.doi10.1088/0957-4484/25/24/245103-
dc.subject.keywordgadolinium-
dc.subject.keywordhigh sensitivity-
dc.subject.keywordimaging agent-
dc.subject.keywordmagnetic resonance image-
dc.subject.localgadolinium-
dc.subject.localhigh sensitivity-
dc.subject.localimaging agent-
dc.subject.localImaging agents-
dc.subject.localmagnetic resonance image-
dc.subject.localMagnetic resonance image-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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