Violapyrones H and I, new cytotoxic compounds isolated from Streptomyces sp. associated with the marine starfish Acanthaster planci

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dc.contributor.authorH J Shin-
dc.contributor.authorH S Lee-
dc.contributor.authorJ S Lee-
dc.contributor.authorJ Shin-
dc.contributor.authorM A Lee-
dc.contributor.authorH S Lee-
dc.contributor.authorY J Lee-
dc.contributor.authorJieun Yun-
dc.contributor.authorJong Soon Kang-
dc.date.accessioned2017-04-19T09:53:28Z-
dc.date.available2017-04-19T09:53:28Z-
dc.date.issued2014-
dc.identifier.issn1660-3397-
dc.identifier.uri10.3390/md12063283ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12006-
dc.description.abstractTwo new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (1-4) exhibited cytotoxicity against 10 human cancer cell lines with GI50 values of 1.10-26.12 μg/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C.-
dc.publisherMDPI-
dc.titleViolapyrones H and I, new cytotoxic compounds isolated from Streptomyces sp. associated with the marine starfish Acanthaster planci-
dc.title.alternativeViolapyrones H and I, new cytotoxic compounds isolated from Streptomyces sp. associated with the marine starfish Acanthaster planci-
dc.typeArticle-
dc.citation.titleMarine Drugs-
dc.citation.number6-
dc.citation.endPage3291-
dc.citation.startPage3283-
dc.citation.volume12-
dc.contributor.affiliatedAuthorJieun Yun-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName신희재-
dc.contributor.alternativeName이화선-
dc.contributor.alternativeName이종석-
dc.contributor.alternativeName신준호-
dc.contributor.alternativeName이민아-
dc.contributor.alternativeName이희승-
dc.contributor.alternativeName이연주-
dc.contributor.alternativeName윤지은-
dc.contributor.alternativeName강종순-
dc.identifier.bibliographicCitationMarine Drugs, vol. 12, no. 6, pp. 3283-3291-
dc.identifier.doi10.3390/md12063283-
dc.subject.keywordAnti-cancer activity-
dc.subject.keywordStarfish-
dc.subject.keywordStreptomyces sp.-
dc.subject.keywordViolapyrones-
dc.subject.keywordα-pyrones-
dc.subject.localAnti-cancer activity-
dc.subject.localAnticancer activity-
dc.subject.localanticancer activity-
dc.subject.localStarfish-
dc.subject.localStreptomyces sp-
dc.subject.localStreptomyces sp.-
dc.subject.localstreptomyces sp.-
dc.subject.localViolapyrones-
dc.subject.localα-pyrones-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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