DC Field | Value | Language |
---|---|---|
dc.contributor.author | E Venkateswararao | - |
dc.contributor.author | V K Sharma | - |
dc.contributor.author | Jieun Yun | - |
dc.contributor.author | Y Kim | - |
dc.contributor.author | S H Jung | - |
dc.date.accessioned | 2017-04-19T09:53:29Z | - |
dc.date.available | 2017-04-19T09:53:29Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | 10.1016/j.bmc.2014.04.045 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12008 | - |
dc.description.abstract | To investigate the anti-proliferative effect of NF-κB inhibitor, a series of analogs of (E)-1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4- hydroxyphenyl)prop-2-en-1-one (5a) were prepared and evaluated for their NF-κB inhibition and anti-proliferative activity against various human cancer cell lines. Compounds (E)-1-(2-(3,3-dimethylbutoxy)-6-hydroxyphenyl)-3- (4-hydroxyphenyl)prop-2-en-1-one (5e) and (E)-4-(3-(2-(3,3-dimethylbutoxy)-6- hydroxyphenyl)-3-oxoprop-1-enyl)benzenesulfonamide (5p) showed good NF-κB inhibition as well as potent anti-proliferative activity. SAR studies showed that all the compounds with potent or moderate NF-κB inhibition displayed good anti-proliferative activity. All the analogs (5b-r) maintained a good correlation between their NF-κB inhibition and anti-proliferative activity though the extent is not directly proportional to each other. | - |
dc.publisher | Elsevier | - |
dc.title | Anti-proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells | - |
dc.title.alternative | Anti-proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry | - |
dc.citation.number | 13 | - |
dc.citation.endPage | 3392 | - |
dc.citation.startPage | 3386 | - |
dc.citation.volume | 22 | - |
dc.contributor.affiliatedAuthor | Jieun Yun | - |
dc.contributor.alternativeName | Venkateswararao | - |
dc.contributor.alternativeName | Sharma | - |
dc.contributor.alternativeName | 윤지은 | - |
dc.contributor.alternativeName | 김영수 | - |
dc.contributor.alternativeName | 정상훈 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry, vol. 22, no. 13, pp. 3386-3392 | - |
dc.identifier.doi | 10.1016/j.bmc.2014.04.045 | - |
dc.subject.keyword | Anti-proliferative activity | - |
dc.subject.keyword | Chalcones | - |
dc.subject.keyword | Inactivation of NF-κB | - |
dc.subject.local | anti-proliferative activity | - |
dc.subject.local | Anti-proliferative activity | - |
dc.subject.local | antiproliferative activity | - |
dc.subject.local | chalcone | - |
dc.subject.local | Chalcones | - |
dc.subject.local | Chalcone | - |
dc.subject.local | Inactivation of NF-κB | - |
dc.description.journalClass | Y | - |
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