Anti-proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells

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dc.contributor.authorE Venkateswararao-
dc.contributor.authorV K Sharma-
dc.contributor.authorJieun Yun-
dc.contributor.authorY Kim-
dc.contributor.authorS H Jung-
dc.date.accessioned2017-04-19T09:53:29Z-
dc.date.available2017-04-19T09:53:29Z-
dc.date.issued2014-
dc.identifier.issn0968-0896-
dc.identifier.uri10.1016/j.bmc.2014.04.045ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12008-
dc.description.abstractTo investigate the anti-proliferative effect of NF-κB inhibitor, a series of analogs of (E)-1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4- hydroxyphenyl)prop-2-en-1-one (5a) were prepared and evaluated for their NF-κB inhibition and anti-proliferative activity against various human cancer cell lines. Compounds (E)-1-(2-(3,3-dimethylbutoxy)-6-hydroxyphenyl)-3- (4-hydroxyphenyl)prop-2-en-1-one (5e) and (E)-4-(3-(2-(3,3-dimethylbutoxy)-6- hydroxyphenyl)-3-oxoprop-1-enyl)benzenesulfonamide (5p) showed good NF-κB inhibition as well as potent anti-proliferative activity. SAR studies showed that all the compounds with potent or moderate NF-κB inhibition displayed good anti-proliferative activity. All the analogs (5b-r) maintained a good correlation between their NF-κB inhibition and anti-proliferative activity though the extent is not directly proportional to each other.-
dc.publisherElsevier-
dc.titleAnti-proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells-
dc.title.alternativeAnti-proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry-
dc.citation.number13-
dc.citation.endPage3392-
dc.citation.startPage3386-
dc.citation.volume22-
dc.contributor.affiliatedAuthorJieun Yun-
dc.contributor.alternativeNameVenkateswararao-
dc.contributor.alternativeNameSharma-
dc.contributor.alternativeName윤지은-
dc.contributor.alternativeName김영수-
dc.contributor.alternativeName정상훈-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry, vol. 22, no. 13, pp. 3386-3392-
dc.identifier.doi10.1016/j.bmc.2014.04.045-
dc.subject.keywordAnti-proliferative activity-
dc.subject.keywordChalcones-
dc.subject.keywordInactivation of NF-κB-
dc.subject.localanti-proliferative activity-
dc.subject.localAnti-proliferative activity-
dc.subject.localantiproliferative activity-
dc.subject.localchalcone-
dc.subject.localChalcones-
dc.subject.localChalcone-
dc.subject.localInactivation of NF-κB-
dc.description.journalClassY-
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