Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1 = 도라지유래 사포닌 platycodin D가 NF-kB, STAT1, 아토피성 피부염 진전 억제

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dc.contributor.authorJ H Choi-
dc.contributor.authorS W Jin-
dc.contributor.authorE H Han-
dc.contributor.authorB H Park-
dc.contributor.authorH G Kim-
dc.contributor.authorT Khanal-
dc.contributor.authorY P Hwang-
dc.contributor.authorM T Do-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorY C Chung-
dc.contributor.authorH S Kim-
dc.contributor.authorT C Jeong-
dc.contributor.authorH G Jeong-
dc.date.accessioned2017-04-19T09:53:43Z-
dc.date.available2017-04-19T09:53:43Z-
dc.date.issued2014-
dc.identifier.issn09447113-
dc.identifier.uri10.1016/j.phymed.2014.04.011ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12012-
dc.description.abstractPurpose The consequences of precipitously rising allergic skin inflammation rates worldwide have accelerated the risk of atopic dermatitis (AD). Natural product-based agents with good efficacy and low risk of side effects offer promising prevention and treatment strategies for inflammation-related diseases. We have already reported that Platycodon grandiflorum root-derived saponins (Changkil saponins, CKS) have many pharmacological effects, including anti-inflammatory and anti-allergic effects, but its influence on AD remains unclear. Therefore, we evaluated the inhibitory effect of CKS, mainly platycodin D, on AD-like skin symptoms in mice and the possible mechanisms in cells. Methods Mice were sensitized and challenged with 2,4-dinitrochlorobenzene (DNCB). Four weeks after challenge, mice were treated with oral administration of CKS for 4 weeks. In addition, cells were used to evaluate the effect of CKS, mainly platycodin D, on the TARC expression regulated mechanism. Results CKS attenuated DNCB-induced dermatitis severity, serum levels of IgE and TARC, and mRNA expression of TARC, TNF-α, IFN-γ, IL-4, IL-5, and IL-13 in mice. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells and mast cells in the ears. Moreover, CKS and platycodin D inhibited TNF-α/IFN-γ- induced TARC expression through the suppression of NF-κB and STAT1 and induction of Nrf2/ARE-mediated hemeoxygenase-1 (HO-1) expression in cells. Conclusion We suggest that CKS and platycodin D inhibited the development of AD-like skin symptoms by regulating cytokine mediators and may be an effective alternative therapy for AD-like skin symptoms.-
dc.publisherElsevier-
dc.titlePlatycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1 = 도라지유래 사포닌 platycodin D가 NF-kB, STAT1, 아토피성 피부염 진전 억제-
dc.title.alternativePlatycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1-
dc.typeArticle-
dc.citation.titlePhytomedicine-
dc.citation.number8-
dc.citation.endPage1061-
dc.citation.startPage1053-
dc.citation.volume21-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.alternativeName최재호-
dc.contributor.alternativeName진선우-
dc.contributor.alternativeName한은희-
dc.contributor.alternativeName박봉환-
dc.contributor.alternativeName김형균-
dc.contributor.alternativeNameKhanal-
dc.contributor.alternativeName황용필-
dc.contributor.alternativeNameDo-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName정영철-
dc.contributor.alternativeName김희석-
dc.contributor.alternativeName정태천-
dc.contributor.alternativeName정혜광-
dc.identifier.bibliographicCitationPhytomedicine, vol. 21, no. 8, pp. 1053-1061-
dc.identifier.doi10.1016/j.phymed.2014.04.011-
dc.subject.keywordAtopic dermatitis-
dc.subject.keywordHO-1-
dc.subject.keywordNF-κB-
dc.subject.keywordPlatycodon grandiflorum-
dc.subject.keywordSaponins-
dc.subject.keywordSTAT1-
dc.subject.localAtopic dermatitis-
dc.subject.localHO-1-
dc.subject.localNF-κB-
dc.subject.localNF-kB-
dc.subject.localPlatycodon grandiflorum-
dc.subject.localSaponins-
dc.subject.localSaponin-
dc.subject.localSTAT1-
dc.description.journalClassY-
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Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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