One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging

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dc.contributor.authorA Kukreja-
dc.contributor.authorEun Kyung Lim-
dc.contributor.authorB Kang-
dc.contributor.authorY Choi-
dc.contributor.authorT Lee-
dc.contributor.authorJ S Suh-
dc.contributor.authorY M Huh-
dc.contributor.authorS Haam-
dc.date.accessioned2017-04-19T09:53:51Z-
dc.date.available2017-04-19T09:53:51Z-
dc.date.issued2014-
dc.identifier.issn1178-2013-
dc.identifier.uri10.2147/IJN.S55525ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12014-
dc.description.abstractIn this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.-
dc.publisherDove Medical Press Ltd-
dc.titleOne-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging-
dc.title.alternativeOne-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging-
dc.typeArticle-
dc.citation.titleInternational Journal of Nanomedicine-
dc.citation.number1-
dc.citation.endPage2498-
dc.citation.startPage2489-
dc.citation.volume9-
dc.contributor.affiliatedAuthorEun Kyung Lim-
dc.contributor.alternativeNameKukreja-
dc.contributor.alternativeName임은경-
dc.contributor.alternativeName강병훈-
dc.contributor.alternativeName최유나-
dc.contributor.alternativeName이택수-
dc.contributor.alternativeName서진석-
dc.contributor.alternativeName허용민-
dc.contributor.alternativeName함승주-
dc.identifier.bibliographicCitationInternational Journal of Nanomedicine, vol. 9, no. 1, pp. 2489-2498-
dc.identifier.doi10.2147/IJN.S55525-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordDextran-
dc.subject.keywordMacrophages-
dc.subject.keywordMagnetic nanocrystal-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.localatherosclerosis-
dc.subject.localAtherosclerosis-
dc.subject.localatheroclerosis-
dc.subject.localDextran-
dc.subject.localdextran-
dc.subject.localmacrophages-
dc.subject.localmacrophage-
dc.subject.localMacrophages-
dc.subject.localMacrophage-
dc.subject.localMagnetic nanocrystal-
dc.subject.localmagnetic resonance imaging (MRI)-
dc.subject.localMagnetic Resonance Imaging-
dc.subject.localmagnetic resonance imaging-
dc.subject.localMagnetic resonance imaging-
dc.subject.localMRI-
dc.subject.localMagnetic resonance imaging (MRI)-
dc.description.journalClassY-
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Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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