Hepatoprotective effects of Gardenia jasminoides ellis extract in nonalcoholic fatty liver disease induced by a high fat diet in C57BL/6 mice

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Title
Hepatoprotective effects of Gardenia jasminoides ellis extract in nonalcoholic fatty liver disease induced by a high fat diet in C57BL/6 mice
Author(s)
Mi Kyung Nam; H R Choi; J S Cho; Soo-Min Cho; Young Ik Lee
Bibliographic Citation
Natural Products Sciences, vol. 20, no. 1, pp. 65-70
Publication Year
2014
Abstract
This study was carried out to investigate the potential effects of Gardenia jasminoides (GJ) extracts, on hepatic steatosis and lipid metabolism in mice fed with high-fat diet (HFD). GJ extracts (100 mg/kg, × 10 weeks) fed mice showed reduced body weight, adipose tissue weight, reduced aminotransferase level in plasma and hepatic lipid (triglyceride, total cholesterol) content. These effects were accompanied by decreased expression of lipogenic genes, sterol regulatory element binding protein-1c (SREBP-1c), liver X receptor (LXR), fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), cluster of differentiation 36 (CD36), lipoprotein lipase (LPL) and decreased lipogenic enzyme FAS and HMG-CoAR enzyme activities while elevating carnitine palmitoyltrasferase-1 (CPT) activity. Based on these results, we speculated that the inhibitory effect on hepatic steatosis of GJ extract containing geniposide is the result of suppression of lipid synthesis in mice fed with HFD, suggesting that GJ extract may be beneficial in preventing hepatic steatosis.
Keyword
Adipose tissueGardenia jasminoidesHepatic steatosisHigh-fat dietLipogenic gene
ISSN
I000-0147
Publisher
Korean Society of Pharmacognosy
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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