DC Field | Value | Language |
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dc.contributor.author | S H Kim | - |
dc.contributor.author | In Chul Lee | - |
dc.contributor.author | H S Baek | - |
dc.contributor.author | C Moon | - |
dc.contributor.author | S H Kim | - |
dc.contributor.author | J C Yoo | - |
dc.contributor.author | In Sik Shin | - |
dc.contributor.author | J C Kim | - |
dc.date.accessioned | 2017-04-19T09:54:01Z | - |
dc.date.available | 2017-04-19T09:54:01Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | 10.1016/j.fct.2014.04.024 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12026 | - |
dc.description.abstract | The protective effects of diallyl disulfide (DADS) on cyclophosphamide (CP)-induced developmental toxicity and the possible mechanisms involved in this protection were investigated in rats. In order to study the mechanisms involved in the protection, we examined the effects of DADS on the expression of cytochrome P450 (CYP) 3A1 in the maternal liver and placenta and oxidative stress in the maternal hepatic tissues caused by CP. CP caused severe embryo-fetal developmental toxicity and hepatic oxidative stress. In contrast, DADS treatment significantly attenuated CP-induced developmental toxicity and oxidative damage in the maternal liver. DADS also significantly increased expression of CYP3A1 in the maternal liver and placenta. These results indicate that the protective effects of DADS against CP-induced developmental toxicity may be due to its ability to promote detoxification of CP, primarily by inducing CYP3A1 expression in the maternal liver and placenta, and its potent antioxidant effects. | - |
dc.publisher | Elsevier | - |
dc.title | Induction of cytochrome P450 3A1 expression by diallyl disulfide: protective effects against cyclophosphamide-induced embryo-fetal developmental toxicity | - |
dc.title.alternative | Induction of cytochrome P450 3A1 expression by diallyl disulfide: protective effects against cyclophosphamide-induced embryo-fetal developmental toxicity | - |
dc.type | Article | - |
dc.citation.title | Food and Chemical Toxicology | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 319 | - |
dc.citation.startPage | 312 | - |
dc.citation.volume | 69 | - |
dc.contributor.affiliatedAuthor | In Chul Lee | - |
dc.contributor.affiliatedAuthor | In Sik Shin | - |
dc.contributor.alternativeName | 김성환 | - |
dc.contributor.alternativeName | 이인철 | - |
dc.contributor.alternativeName | 백형선 | - |
dc.contributor.alternativeName | 문창종 | - |
dc.contributor.alternativeName | 김성호 | - |
dc.contributor.alternativeName | 유진철 | - |
dc.contributor.alternativeName | 신인식 | - |
dc.contributor.alternativeName | 김종춘 | - |
dc.identifier.bibliographicCitation | Food and Chemical Toxicology, vol. 69, pp. 312-319 | - |
dc.identifier.doi | 10.1016/j.fct.2014.04.024 | - |
dc.subject.keyword | Cyclophosphamide | - |
dc.subject.keyword | Cytochrome P450 3A1 | - |
dc.subject.keyword | Developmental toxicity | - |
dc.subject.keyword | Diallyl disulfide | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.local | Cyclophosphamide | - |
dc.subject.local | Cytochrome P450 3A1 | - |
dc.subject.local | Developmental toxicity | - |
dc.subject.local | developmental toxicity | - |
dc.subject.local | Diallyl disulfide | - |
dc.subject.local | diallyl disulfide | - |
dc.subject.local | Oxidative stre | - |
dc.subject.local | Oxidative stress | - |
dc.subject.local | OXIDATIVE STRESS | - |
dc.subject.local | Oxidative Stress | - |
dc.subject.local | oxidative stress | - |
dc.description.journalClass | Y | - |
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