Induction of cytochrome P450 3A1 expression by diallyl disulfide: protective effects against cyclophosphamide-induced embryo-fetal developmental toxicity

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dc.contributor.authorS H Kim-
dc.contributor.authorIn Chul Lee-
dc.contributor.authorH S Baek-
dc.contributor.authorC Moon-
dc.contributor.authorS H Kim-
dc.contributor.authorJ C Yoo-
dc.contributor.authorIn Sik Shin-
dc.contributor.authorJ C Kim-
dc.date.accessioned2017-04-19T09:54:01Z-
dc.date.available2017-04-19T09:54:01Z-
dc.date.issued2014-
dc.identifier.issn0278-6915-
dc.identifier.uri10.1016/j.fct.2014.04.024ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12026-
dc.description.abstractThe protective effects of diallyl disulfide (DADS) on cyclophosphamide (CP)-induced developmental toxicity and the possible mechanisms involved in this protection were investigated in rats. In order to study the mechanisms involved in the protection, we examined the effects of DADS on the expression of cytochrome P450 (CYP) 3A1 in the maternal liver and placenta and oxidative stress in the maternal hepatic tissues caused by CP. CP caused severe embryo-fetal developmental toxicity and hepatic oxidative stress. In contrast, DADS treatment significantly attenuated CP-induced developmental toxicity and oxidative damage in the maternal liver. DADS also significantly increased expression of CYP3A1 in the maternal liver and placenta. These results indicate that the protective effects of DADS against CP-induced developmental toxicity may be due to its ability to promote detoxification of CP, primarily by inducing CYP3A1 expression in the maternal liver and placenta, and its potent antioxidant effects.-
dc.publisherElsevier-
dc.titleInduction of cytochrome P450 3A1 expression by diallyl disulfide: protective effects against cyclophosphamide-induced embryo-fetal developmental toxicity-
dc.title.alternativeInduction of cytochrome P450 3A1 expression by diallyl disulfide: protective effects against cyclophosphamide-induced embryo-fetal developmental toxicity-
dc.typeArticle-
dc.citation.titleFood and Chemical Toxicology-
dc.citation.number0-
dc.citation.endPage319-
dc.citation.startPage312-
dc.citation.volume69-
dc.contributor.affiliatedAuthorIn Chul Lee-
dc.contributor.affiliatedAuthorIn Sik Shin-
dc.contributor.alternativeName김성환-
dc.contributor.alternativeName이인철-
dc.contributor.alternativeName백형선-
dc.contributor.alternativeName문창종-
dc.contributor.alternativeName김성호-
dc.contributor.alternativeName유진철-
dc.contributor.alternativeName신인식-
dc.contributor.alternativeName김종춘-
dc.identifier.bibliographicCitationFood and Chemical Toxicology, vol. 69, pp. 312-319-
dc.identifier.doi10.1016/j.fct.2014.04.024-
dc.subject.keywordCyclophosphamide-
dc.subject.keywordCytochrome P450 3A1-
dc.subject.keywordDevelopmental toxicity-
dc.subject.keywordDiallyl disulfide-
dc.subject.keywordOxidative stress-
dc.subject.localCyclophosphamide-
dc.subject.localCytochrome P450 3A1-
dc.subject.localDevelopmental toxicity-
dc.subject.localdevelopmental toxicity-
dc.subject.localDiallyl disulfide-
dc.subject.localdiallyl disulfide-
dc.subject.localOxidative stre-
dc.subject.localOxidative stress-
dc.subject.localOXIDATIVE STRESS-
dc.subject.localOxidative Stress-
dc.subject.localoxidative stress-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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