Therapeutically targeting neuroinflammation and microglia after acute ischemic stroke

Cited 95 time in scopus
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Title
Therapeutically targeting neuroinflammation and microglia after acute ischemic stroke
Author(s)
Youngjeon Lee; Sang-Rae Lee; S S Choi; Hyeon-Gu Yeo; Kyu Tae Chang; H J Lee
Bibliographic Citation
Biomed Research International, vol. 2014, pp. 297241-297241
Publication Year
2014
Abstract
Inflammation has a pivotal role in the pathogenesis of ischemic stroke, and recent studies posit that inflammation acts as a double-edged sword, not only detrimentally augmenting secondary injury, but also potentially promoting recovery. An initial event of inflammation in ischemic stroke is the activation of microglia, leading to production of both pro- and anti-inflammatory mediators acting through multiple receptor signaling pathways. In this review, we discuss the role of microglial mediators in acute ischemic stroke and elaborate on preclinical and clinical studies focused on microglia in stroke models. Understanding how microglia can lead to both pro- and anti-inflammatory responses may be essential to implement therapeutic strategies using immunomodulatory interventions in ischemic stroke.
ISSN
2314-6133
Publisher
Hindawi Ltd
DOI
http://dx.doi.org/10.1155/2014/297241
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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