Ameliorative effects of pine bark extract on spermatotoxicity by alpha-chlorohydrin in rats

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Ameliorative effects of pine bark extract on spermatotoxicity by alpha-chlorohydrin in rats
S H Kim; In Chul Lee; H S Baek; C Moon; C S Bae; S H Kim; S C Park; Hyoung-Chin Kim; J C Kim
Bibliographic Citation
Phytotherapy Research, vol. 28, no. 3, pp. 451-457
Publication Year
We investigated the protective effects of pine bark extract (Pycnogenol®, PYC, Horphag Research Ltd., Route de Belis, France) against α-chlorohydrin (ACH)-induced spermatotoxicity in rats. Rats were orally administered ACH (30 mg/kg/day) with or without PYC (20 mg/kg/day) for 7 days. Administration of ACH significantly decreased sperm motility. α-Chlorohydrin also caused histopathological alterations and apoptotic changes in caput epididymides. An increased malondialdehyde concentration and decreased glutathione content, as well as catalase and glutathione peroxidase activities were also found. In contrast, PYC treatment significantly prevented ACH-induced spermatotoxicity, including decreased sperm motility, histopathological lesions, and apoptotic changes in the caput epididymis. Pycnogenol® also had an antioxidant benefit by decreasing malondialdehyde and increasing levels of the antioxidant glutathione and the activities of the antioxidant enzymes catalase and peroxidase in epididymal tissues. These results indicate that PYC treatment attenuated ACH-induced spermatotoxicity through antioxidant and antiapoptotic effects.
oxidative stressprotective effectsPycnogenol®spermatotoxicityα-chlorohydrin
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Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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