Flavonoids from Lindera glauca Blume as low-density lipoprotein oxidation inhibitors

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Title
Flavonoids from Lindera glauca Blume as low-density lipoprotein oxidation inhibitors
Author(s)
G W Huh; J H Park; Ji Hyun Kang; Tae Sook Jeong; H C Kang; N I Baek
Bibliographic Citation
Natural Product Research, vol. 28, no. 11, pp. 831-834
Publication Year
2014
Abstract
In order to identify antioxidant flavonoids from Lindera glauca Blume, we performed phytochemical analysis of L. glauca Blume heartwood and isolated eight flavonoids - lindeglaucol (1), lindeglaucone (2), cilicicone B (3), tamarixetin 3-O-α-L-rhamnoside (4), procyanidin A2 (5), cinnamtannin B1 (6), cinnamtannin D1 (7), and procyanidin A1 (8) - through repeated column chromatography over silica gel (SiO2), octadecyl silica gel (ODS) and Sephadex LH-20. The chemical structures of compounds 1-8 were elucidated from spectroscopic data (NMR, IR and MS). The low-density lipoprotein oxidation inhibitory activities of the isolated compounds were evaluated in vitro by using the thiobarbituric acid reactive substances assay. Compounds 5-8 exhibited high inhibition activity, comparable to the positive control butyl hydroxyl toluene. Compounds 2 and 3 were slightly less active, while 1 and 4 expressed low activity.
Keyword
FlavonoidLDL-oxidationLindera glaucaNMR
ISSN
1029-2349
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/14786419.2013.879583
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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