Magnetic nanoclusters engineered by polymer-controlled self-assembly for the accurate diagnosis of atherosclerotic plaques via magnetic resonance imaging

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dc.contributor.authorM H Kim-
dc.contributor.authorB Kim-
dc.contributor.authorEun Kyung Lim-
dc.contributor.authorY Choi-
dc.contributor.authorJ Choi-
dc.contributor.authorE Kim-
dc.contributor.authorE Jang-
dc.contributor.authorH S Park-
dc.contributor.authorJ S Suh-
dc.contributor.authorY M Huh-
dc.contributor.authorS Haam-
dc.date.accessioned2017-04-19T09:55:13Z-
dc.date.available2017-04-19T09:55:13Z-
dc.date.issued2014-
dc.identifier.issn1616-5187-
dc.identifier.uri10.1002/mabi.201400029ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12090-
dc.description.abstractOleyl dextran-coated magnetic nanoclusters (ODMCs) are fabricated for the accurate detection of macrophage-rich atherosclerotic plaques using magnetic resonance (MR) imaging. Dextran is introduced to the cluster surface of magnetic nanocrystals (MNCs) through self-assembly using amphiphilic oleic acid-conjugated dextran (ODex) to provide not only hydrophilicity but also a high affinity to macrophages. Enhanced magnetism of the ODMCs is engineered by optimizing the degree of substitution (DS) of the oleyl group in ODex and the concentration of ODex used for the synthesis of ODMC. Consequently, ODMCs exhibit significantly increased T2 relaxivity and excellent macrophage-targeting ability without cytotoxicity, in vitro. Moreover, in vivo T2-weighted MR imaging after intravenous injection of ODMCs into a rat artery balloon injury model demonstrates considerable MR contrast strength efficacy in the plaques of the injured carotid artery. These novel ODMCs may offer a highly efficient MR imaging nanoprobes for the selective diagnosis of atherosclerosis. Oleyl dextran (ODex) coated magnetic nanocluster (ODMC) is developed and engineered by polymer-controlled self-assembly to be used as efficient MR imaging nanoprobe of atherosclerosis. T2 relaxivity of ODMCs is highly enhanced by controlling the condition of ODex including the degree of substitution of the oleyl group and the concentration used for the synthesis of ODMCs.-
dc.publisherWiley-
dc.titleMagnetic nanoclusters engineered by polymer-controlled self-assembly for the accurate diagnosis of atherosclerotic plaques via magnetic resonance imaging-
dc.title.alternativeMagnetic nanoclusters engineered by polymer-controlled self-assembly for the accurate diagnosis of atherosclerotic plaques via magnetic resonance imaging-
dc.typeArticle-
dc.citation.titleMacromolecular Bioscience-
dc.citation.number7-
dc.citation.endPage952-
dc.citation.startPage943-
dc.citation.volume14-
dc.contributor.affiliatedAuthorEun Kyung Lim-
dc.contributor.alternativeName김명훈-
dc.contributor.alternativeName김봉준-
dc.contributor.alternativeName임은경-
dc.contributor.alternativeName최유나-
dc.contributor.alternativeName최지혜-
dc.contributor.alternativeName김은정-
dc.contributor.alternativeName장은지-
dc.contributor.alternativeName박효선-
dc.contributor.alternativeName서진석-
dc.contributor.alternativeName허용민-
dc.contributor.alternativeName함승주-
dc.identifier.bibliographicCitationMacromolecular Bioscience, vol. 14, no. 7, pp. 943-952-
dc.identifier.doi10.1002/mabi.201400029-
dc.subject.keywordatherosclerotic plaque-
dc.subject.keyworddextran-
dc.subject.keywordimaging-
dc.subject.keywordmagnetic nanoclusters-
dc.subject.keywordself-assembly-
dc.subject.localatherosclerotic plaque-
dc.subject.localDextran-
dc.subject.localdextran-
dc.subject.localImaging-
dc.subject.localimaging-
dc.subject.localmagnetic nanoclusters-
dc.subject.localself-assembly-
dc.subject.localSelf-assembly-
dc.subject.localself assembly-
dc.subject.localSelf-Assembly-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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