Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3 = Ginsenoside의 HRV, CVB3, EV71에 대한 항바이러스 효과

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Title
Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3 = Ginsenoside의 HRV, CVB3, EV71에 대한 항바이러스 효과
Author(s)
J H Song; H J Choi; Hyeok Hwan Song; E H Hong; B R Lee; Sei-Ryang Oh; Kwangman Choi; S G Yeo; Y P Lee; Sungchan Cho; H J Ko
Bibliographic Citation
Journal of Ginseng Research, vol. 38, no. 3, pp. 173-179
Publication Year
2014
Abstract
Background: Ginsenosides are the major components responsible for the biochemical and pharmacological actions of ginseng, and have been shown to have various biological activities. In this study, we investigated the antiviral activities of seven ginsenosides [protopanaxatriol (PT) type: Re, Rf, and Rg2; protopanaxadiol (PD) type: Rb1, Rb2, Rc, and Rd)] against coxsackievirus B3 (CVB3), enterovirus 71 (EV71), and human rhinovirus 3 (HRV3). Methods: Assays of antiviral activity and cytotoxicity were evaluated by the sulforhodamine B method using the cytopathic effect (CPE) reduction assay. Results: The antiviral assays demonstrated that, of the seven ginsenosides, the PT-type ginsenosides (Re, Rf, and Rg2) possess significant antiviral activities against CVB3 and HRV3 at a concentration of 100 μg/mL. Among the PT-type ginsenosides, only ginsenoside Rg2 showed significant anti-EV71 activity with no cytotoxicity to cells at 100 μg/mL. The PD-type ginsenosides (Rb1, Rb2, Rc, and Rd), by contrast, did not show any significant antiviral activity against CVB3, EV71, and HRV3, and exhibited cytotoxic effects to virus-infected cells. Notably, the antiviral efficacies of PT-type ginsenosides were comparable to those of ribavirin, a commonly used antiviral drug. Conclusion: Collectively, our findings suggest that the ginsenosides Re, Rf, and Rg2 have the potential to be effective in the treatment of CVB3, EV71, and HRV3 infection.
Keyword
Antiviral activityCVB3EV71GinsenosidesHRV3
ISSN
1226-8453
Publisher
South Korea
DOI
http://dx.doi.org/10.1016/j.jgr.2014.04.003
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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