Identification of lactoferrin as a human dedifferentiation factor through the studies of reptile tissue regeneration mechanisms

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dc.contributor.authorK S Bae-
dc.contributor.authorSun Young Kim-
dc.contributor.authorS Y Park-
dc.contributor.authorA J Jeong-
dc.contributor.authorH H Lee-
dc.contributor.authorJungwoon Lee-
dc.contributor.authorYee Sook Cho-
dc.contributor.authorS H Leem-
dc.contributor.authorT H Kang-
dc.contributor.authorKwang-Hee Bae-
dc.contributor.authorJ H Kim-
dc.contributor.authorY W Jung-
dc.contributor.authorW Jun-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorSang Chul Lee-
dc.contributor.authorJ W Chung-
dc.date.accessioned2017-04-19T09:55:22Z-
dc.date.available2017-04-19T09:55:22Z-
dc.date.issued2014-
dc.identifier.issn1017-7825-
dc.identifier.uri10.4014/jmb.1402.02009ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12104-
dc.description.abstractIn this study, we performed two-dimensional electrophoresis with protein extracts from lizard tails, and analyzed the protein expression profiles during the tissue regeneration to identify the dedifferentiation factor. As a result, we identified 18 protein spots among total of 292 spots, of which proteins were specifically expressed during blastema formation. We selected lactoferrin as a candidate because it is the mammalian homolog of leech-derived tryptase inhibitor, which showed the highest frequency among the 18 proteins. Lactoferrin was specifically expressed in various stem cell lines, and enhanced the efficiency of iPSC generation upto approximately 7-fold relative to the control. Furthermore, lactoferrin increased the efficiency by 2-fold without enforced expression of Klf4. These results suggest that lactoferrin may induce dedifferentiation, at least partly by increasing the expression of Klf4.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleIdentification of lactoferrin as a human dedifferentiation factor through the studies of reptile tissue regeneration mechanisms-
dc.title.alternativeIdentification of lactoferrin as a human dedifferentiation factor through the studies of reptile tissue regeneration mechanisms-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number6-
dc.citation.endPage878-
dc.citation.startPage869-
dc.citation.volume24-
dc.contributor.affiliatedAuthorSun Young Kim-
dc.contributor.affiliatedAuthorJungwoon Lee-
dc.contributor.affiliatedAuthorYee Sook Cho-
dc.contributor.affiliatedAuthorKwang-Hee Bae-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorSang Chul Lee-
dc.contributor.alternativeName배길수-
dc.contributor.alternativeName김선영-
dc.contributor.alternativeName박순용-
dc.contributor.alternativeName정애진-
dc.contributor.alternativeName이현희-
dc.contributor.alternativeName이정운-
dc.contributor.alternativeName조이숙-
dc.contributor.alternativeName임선희-
dc.contributor.alternativeName강태홍-
dc.contributor.alternativeName배광희-
dc.contributor.alternativeName김재호-
dc.contributor.alternativeName정용우-
dc.contributor.alternativeName전우진-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName이상철-
dc.contributor.alternativeName정진웅-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 24, no. 6, pp. 869-878-
dc.identifier.doi10.4014/jmb.1402.02009-
dc.subject.keywordDedifferentiation-
dc.subject.keywordIPSCs-
dc.subject.keywordLactoferrin-
dc.subject.keywordStem cell-
dc.subject.keywordTissue regeneration-
dc.subject.localde-differentiation-
dc.subject.localDedifferentiation-
dc.subject.localiPSCs-
dc.subject.localIPSCs-
dc.subject.localLactoferrin-
dc.subject.locallactoferrin-
dc.subject.localstem cells-
dc.subject.localstem cell-
dc.subject.localStem cell-
dc.subject.localStem cells-
dc.subject.localStem Cell-
dc.subject.localTissue regeneration-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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