Chemical composition, anti-inflammatory activity and cytotoxic activity of the liposoluble constituents from different parts of Acanthopanax evodiaefolius by the Herbal Blitzkrieg Extractor

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Title
Chemical composition, anti-inflammatory activity and cytotoxic activity of the liposoluble constituents from different parts of Acanthopanax evodiaefolius by the Herbal Blitzkrieg Extractor
Author(s)
W C Huang; Z Li; X J Li; L M Gong; X Q Liu; Ok-Kyoung Kwon; H X Ye; Hyeong Kyu Lee
Bibliographic Citation
Environmental Toxicology and Pharmacology, vol. 38, no. 2, pp. 406-411
Publication Year
2014
Abstract
The liposoluble constituents of leaves (LCL) and stem barks (LCSB) from Acanthopanax evodiaefolius Franch were extracted by Herbal Blitzkrieg Extractor (HBE), and their chemical composition was analyzed by GC-MS. 18 compounds were identified, representing 71.98% of LCL, while 35 compounds were identified, accounting for 98.28% of the LCSB. Their cytotoxic activity and inhibitory effect on nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells were tested and the LCL showed significant NO, IL-6 and TNF-α inhibition activity. These results provide the scientific basis for looking for new natural anti-inflammatory substances and exploiting and developing resources of A. evodiaefolius Franch.
Keyword
Anti-inflammatoryCytotoxic activityHerbal blitzkrieg extractorLiposoluble constituentsNitric oxideAcanthopanax evodiaefolius
ISSN
1382-6689
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.etap.2014.07.005
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
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