The lactone form of stachybotrydial: a new inhibitor of dihydrofolate reductase from Stachybotrys sp. FN298

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dc.contributor.authorYun Ju Kwon-
dc.contributor.authorMi-Jin Sohn-
dc.contributor.authorHyun Ju Kim-
dc.contributor.authorWon Gon Kim-
dc.date.accessioned2017-04-19T09:55:27Z-
dc.date.available2017-04-19T09:55:27Z-
dc.date.issued2014-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.b14-00108ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12119-
dc.description.abstractDihydrofolate reductase (DHFR) has been confirmed to be a novel target for antibacterial drug development. In this study, we determined that a fungal metabolite from Stachybotrys sp. FN298 can inhibit the DHFR of Staphylococcus aureus. Its structure was identified as a lactone form of stachybotrydial using mass spectrometry and nuclear magnetic resonance analysis. This compound inhibited S. aureus DHFR with a half-maximal inhibitory concentration of 41 μM. It also prevented the growth of S. aureus and methicillinresistant S. aureus (MRSA) with a minimum inhibitory concentration of 32 μg?mL-1. To our knowledge, this is the first description of a DHFR inhibitor of microbial origin. The inhibitory function of the lactone form of stachybotrydial highlights its potential for development into a new broad-spectrum antibacterial agent and as an agent against MRSA.-
dc.publisherPharmaceutical Soc Japan-
dc.titleThe lactone form of stachybotrydial: a new inhibitor of dihydrofolate reductase from Stachybotrys sp. FN298-
dc.title.alternativeThe lactone form of stachybotrydial: a new inhibitor of dihydrofolate reductase from Stachybotrys sp. FN298-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number8-
dc.citation.endPage1410-
dc.citation.startPage1406-
dc.citation.volume37-
dc.contributor.affiliatedAuthorYun Ju Kwon-
dc.contributor.affiliatedAuthorMi-Jin Sohn-
dc.contributor.affiliatedAuthorHyun Ju Kim-
dc.contributor.affiliatedAuthorWon Gon Kim-
dc.contributor.alternativeName권윤주-
dc.contributor.alternativeName손미진-
dc.contributor.alternativeName김현주-
dc.contributor.alternativeName김원곤-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 37, no. 8, pp. 1406-1410-
dc.identifier.doi10.1248/bpb.b14-00108-
dc.subject.keywordDihydrofolate reductase-
dc.subject.keywordStachybotrydial-
dc.subject.keywordStachybotrys-
dc.subject.keywordStaphylococcus aureus-
dc.subject.localDihydrofolate reductase-
dc.subject.localdihydrofolate reductase-
dc.subject.localStachybotrydial-
dc.subject.localStachybotrys-
dc.subject.localStaphylococcus aureus-
dc.subject.localstaphylococcus aureus-
dc.description.journalClassY-
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Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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